Long-term potentiation in rat prefrontal slices facilitated by phased application of dopamine

被引：37

作者：

Blond, O ^{[1
]}

Crépel, F ^{[1
]}

Otani, S ^{[1
]}

机构：

[1] Univ Paris 06, FRE 2371, UMR 7102, F-75005 Paris, France

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2002年 / 438卷 / 1-2期

关键词：

long term potentiation; dopamine; cortex; prefrontal;

D O I：

10.1016/S0014-2999(02)01291-8

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We have previously shown that coupling bath application of dopamine with 50 Hz tetani induces long-term depression in rat prefrontal slices [Neuroscience 85 (1998) 669]. Here, we report a reliable protocol for inducing long-term potentiation in the same preparation. Long-term potentiation was induced by the same dopamine-tetani coupling protocol when the coupling was preceded (similar to30 min) by a single bath application of dopamine. We suggest that metaplastic processes triggered by the first application of dopamine might underlie the LTP induction. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：115 / 116

页数：2

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