Feasibility of diffuse optical imaging with long-lived luminescent probes

被引：15

作者：

Apreleva, SV ^{[1
]}

Wilson, DE ^{[1
]}

Vinogradov, SA ^{[1
]}

机构：

[1] Univ Penn, Dept Biochem & Biophys, Philadelphia, PA 19104 USA

来源：

OPTICS LETTERS | 2006年 / 31卷 / 08期

关键词：

D O I：

10.1364/OL.31.001082

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

Long-lived near-infrared phosphors with high quantum yields have recently become available, making it possible to image oxygen distributions in tissue in three dimensions. By numerical simulations we demonstrate that, by using phosphorescent probes with appropriate oxygen quenching constants, one can image hypoxic phantoms in scattering media with adequate spatial resolution, employing simple time-gated measurements. The approach developed will guide experimental imaging of phosphorescence lifetime and oxygen pressure in living tissue. (c) 2006 Optical Society of America.

引用

页码：1082 / 1084

页数：3

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