Partial inhibition of the in vitro infection of adult mouse dorsal root ganglion neurons by rabies virus using nicotinic antagonists

被引：13

作者：

Castellanos, JE ^{[1
]}

Castaneda, DR ^{[1
]}

Velandia, AE ^{[1
]}

Hurtado, H ^{[1
]}

机构：

[1] INST NACL SALUD,SUBDIRECC IND,BOGOTA,COLOMBIA

来源：

NEUROSCIENCE LETTERS | 1997年 / 229卷 / 03期

关键词：

rabies; dorsal root ganglia; receptor; nicotinic antagonists; adult mouse; cell culture;

D O I：

10.1016/S0304-3940(97)00440-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The infection of target cells by rabies virus is effected through membrane receptors. Several authors have suggested that nicotinic receptors could be used by this virus, but no direct experimental evidence is available. In this study mouse dorsal root ganglia cells were treated with various nicotinic antagonists (dihydro-beta-eritroidine, mecamilamine, d-tubocurarin, hexametonium, alpha-bungarotoxin and erabutoxin). After incubation. the cultures were infected with rabies virus. Cells were fixed, and processed for immunodetection of rabies virus. Treatment with mecamilamine or d-tubocurarine reduced the percentage of infected neurons. None of the antagonists tested changed the percentage of infected non-neuronal cells. (C) 1997 Elsevier Science Ireland Ltd.

引用

页码：198 / 200

页数：3

共 27 条

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