Frequency and significance of antinuclear antibodies in multiple sclerosis

被引：69

作者：

Collard, RC ^{[1
]}

Koehler, RPM ^{[1
]}

Mattson, DH ^{[1
]}

机构：

[1] UNIV ROCHESTER,SCH MED & DENT,DEPT NEUROL,ROCHESTER,NY 14642

来源：

NEUROLOGY | 1997年 / 49卷 / 03期

关键词：

D O I：

10.1212/WNL.49.3.857

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

In a prospective sample of patients with multiple sclerosis (MS) we found a high frequency of antinuclear antibodies (ANA), 22.5%, confirming results from previous studies. ANA occurrence did not correlate with gender, age, duration of MS, MS course, or disability in either the prospective and retrospective samples of MS patients. In 16 patients with MS tested at two time points, ANA occurrence did correlate with MS disease activity. This suggests that the high frequency of ANA in MS reflects ongoing immune dysregulation.

引用

页码：857 / 861

页数：5

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