The effects of D1 or D2 dopamine receptor antagonism in the medial preoptic area, ventral pallidum, or nucleus accumbens on the maternal retrieval response and other aspects of maternal behavior in rats

被引：132

作者：

Numan, M ^{[1
]}

Numan, MJ ^{[1
]}

Pliakou, N ^{[1
]}

Stolzenberg, DS ^{[1
]}

Mullins, OJ ^{[1
]}

Murphy, JM ^{[1
]}

Smith, CD ^{[1
]}

机构：

[1] Boston Coll, Dept Psychol, Chestnut Hill, MA 02467 USA

来源：

BEHAVIORAL NEUROSCIENCE | 2005年 / 119卷 / 06期

关键词：

maternal behavior; nucleus accumbens; D1; receptor; medial preoptic area; ventral pallidum;

D O I：

10.1037/0735-7044.119.6.1588

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

The medial preoptic area (MPOA), ventral pallidum (VP), and nucleus accumbens (NA) receive dopaminergic afferents and are involved in maternal behavior. Experiments investigated whether dopamine (DA) receptor antagonism in NA disrupts maternal behavior, determined the type of DA receptor involved, and investigated the involvement of drug spread to VP or MPOA. Injection of SCH 23390 (D1 DA receptor antagonist) into NA of postpartum rats disrupted retrieving at dosage levels that were ineffective when injected into MPOA or VP. Motor impairment was not the cause of the deficit. Injection of eticlopride (D2 DA receptor antagonist) into NA or VP was without effect. Results emphasize the importance of DA action on D1 receptors in NA for retrieval behavior.

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收藏

页码：1588 / 1604

页数：17

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