Alternate signalling pathways from the interleukin-2 receptor

被引：89

作者：

Ellery, JM ^{[1
]}

Nicholls, PJ ^{[1
]}

机构：

[1] Univ Kent, Dept Biosci, Canterbury CT2 7NJ, Kent, England

来源：

CYTOKINE & GROWTH FACTOR REVIEWS | 2002年 / 13卷 / 01期

关键词：

interleukin-2 receptor (IL-2R); Jak3; phosphatidylinositol 3 kinase (PI3K);

D O I：

10.1016/S1359-6101(01)00023-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Interleukin-2 (IL-2) plays a major role in the proliferation of cell populations during an immune reaction. The beta(c) and gamma(c) subunits of the IL-2 receptor (IL-2R) are sufficient and necessary for signal transduction. Despite lacking known catalytic domains, receptor engagement leads to the activation of a diverse array protein tyrosine kinases (PTKs). In resting or anergised T cells, Jak3 is not activated. Signals arising from the PROX domain of the gamma(c) subunit activate p56(lck) (lck) leading to the induction of anti-apoptotic mechanisms. When Jak3 is activated, in primed T cells, other PTKs predominately mediate the induction of anti-apoptotic mechanisms and drive cellular proliferation. This review intends to suggest a role for these differences within the context of the immune system. (C) 2002 Published by Elsevier Science Ltd.

引用

页码：27 / 40

页数：14

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