Competitive endogenous RNA in colorectal cancer: A systematic review

被引:88
作者
Han Shuwen [1 ]
Zhou Qing [2 ]
Zheng Yan [3 ]
Yang Xi [4 ]
机构
[1] Huzhou Cent Hosp, Dept Med Oncol, Huzhou, Zhejiang, Peoples R China
[2] Huzhou Cent Hosp, Dept Crit Care Med, Huzhou, Zhejiang, Peoples R China
[3] Huzhou Cent Hosp, Dept Pathol, Huzhou, Zhejiang, Peoples R China
[4] Huzhou Cent Hosp, Dept Intervent & Radiotherapy, Huzhou, Zhejiang, Peoples R China
关键词
Colorectal cancer; ceRNA; lncRNA; microRNA; RNA; OXALIPLATIN RESISTANCE; CERNA; PROMOTES; NETWORK; METASTASIS; DATABASE; SPONGES; PLANT;
D O I
10.1016/j.gene.2017.12.036
中图分类号
Q3 [遗传学];
学科分类号
071007 [遗传学];
摘要
Colorectal cancer is one of the most common malignant tumours. Competitive endogenous RNA (ceRNA) networks have been hypothesized, in which various RNAs regulate each other's expression using microRNA response elements (MREs). Recent evidence has highlighted the crucial regulatory roles of ceRNA networks in colorectal cancer. In this review, we summarize the present research methods as well as the currently known ceRNA competitors and targets in colorectal cancer. In addition, we discuss the significance of ceRNA and shortcomings of current studies of colorectal cancer.
引用
收藏
页码:157 / 162
页数:6
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