Probing the mechanism of action of amphotericin B.

被引：7

作者：

James, PR ^{[1
]}

Rawlings, BJ ^{[1
]}

机构：

[1] UNIV LEICESTER,DEPT CHEM,LEICESTER LE1 7RH,LEICS,ENGLAND

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 05期

关键词：

amphotericin B; ion channel;

D O I：

10.1016/0960-894X(96)00059-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Transmembrane spanning dimers of cholesterol were unable to form ion channels with amphotericin B: We suggest that the two 'half pores' as proposed by De Kruijff(1) may be aligned unsymmetrically.

引用

页码：505 / 508

页数：4

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