Integrins in mammary-stem-cell biology and breast-cancer progression - a role in cancer stem cells?

被引：65

作者：

Pontier, Stephanie M. ^{[1
]}

Muller, William J. ^{[1
]}

机构：

[1] McGill Univ, Goodman Canc Ctr, Montreal, PQ H3A 1A3, Canada

来源：

JOURNAL OF CELL SCIENCE | 2009年 / 122卷 / 02期

关键词：

Breast cancer; Cancer stem cells; Integrin; Stem cells; EPITHELIAL-MESENCHYMAL TRANSITION; MITOTIC SPINDLE ORGANIZATION; TUMOR HETEROGENEITY; GENE-EXPRESSION; MOUSE MODELS; DIFFERENTIATION; GLAND; ADHESION; BETA-1-INTEGRIN; TUMORIGENESIS;

D O I：

10.1242/jcs.040394

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cancer cells with stem cell-like properties (cancer stem cells) are believed to drive cancer and are associated with poor prognosis. Data from mouse models have demonstrated that integrins, the major cellular receptors for extracellular-matrix components, have essential roles both during cancer initiation and progression, and during cell differentiation in normal development. By presenting an overview of the role of integrins in stem-cell biology and in cancer progression, this Commentary aims to present evidence for a role of integrins in the biology of cancer stem cells. Given the recent interest in the role of integrins in breast-cancer initiation and progression, we focus on the role of the members of the integrin family and their coupled signaling pathways in mammary-gland development and tumorigenesis.

引用

页码：207 / 214

页数：8

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