Nobilisitine A and B, two masanane-type alkaloids from Clivia nobilis

被引：24

作者：

Evidente, A

Abou-Donia, AH

Darwish, FA

Amer, ME

Kassem, FF

Hammoda, HAM

Motta, A

机构：

[1] Univ Naples Federico II, Dipartimento Sci Chim Agrarie, I-80055 Portici, Italy

[2] Univ Alexandria, Dept Pharmacognosy, Alexandria, Egypt

[3] CNR, Ist Chim Mol Interesse Biol, I-80072 Arco, Italy

来源：

PHYTOCHEMISTRY | 1999年 / 51卷 / 08期

关键词：

Clivia nobilis; Amaryllidaceae; masanane-type alkaloids; nobilsiitine A and B; clivatine epimer;

D O I：

10.1016/S0031-9422(98)00714-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two masanane-type lactone alkaloids, named nobilisitine A and B, were isolated from Egyptian Clivia nobilis and characterized by spectroscopic and chemical methods. Both compounds showed contain the same [2]benzopyrano[3,4-g]indole ring system and therefore belong to the same subgroup of Amaryllidaceae alkaloids. In particular, nobilisitine A and B, reported as two new alkaloids, proved to be the 5 beta-hydroxy-3a,11c-epi-masan-7-one and the 3-hydroxybutanoyl ester of clivonine (5 alpha-hydroxy-5a-epi-masan-7-one), the alkaloid previously extracted from Clivia miniata and belonging to the same alkaloid subgroup. Nobilisitine B appears to be an epimer at the acyl side chain of clivatine. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：1151 / 1155

页数：5

共 15 条

[1] CLIVONIDINE, A NEW ALKALOID FROM CLIVIA-MINIATA
ALI, AA
ROSS, SA
ELMOGHAZY, AM
ELMOGHAZY, SA
[J]. JOURNAL OF NATURAL PRODUCTS, 1983, 46 (03): : 350 - 352
[2] H-1 AND C-13 ASSIGNMENTS FROM SENSITIVITY-ENHANCED DETECTION OF HETERONUCLEAR MULTIPLE-BOND CONNECTIVITY BY 2D MULTIPLE QUANTUM NMR
BAX, A
SUMMERS, MF
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1986, 108 (08) : 2093 - 2094
[3] COMPARISON OF DIFFERENT MODES OF 2-DIMENSIONAL REVERSE-CORRELATION NMR FOR THE STUDY OF PROTEINS
BAX, A
IKURA, M
KAY, LE
TORCHIA, DA
TSCHUDIN, R
[J]. JOURNAL OF MAGNETIC RESONANCE, 1990, 86 (02) : 304 - 318
[4] INVESTIGATION OF COMPLEX NETWORKS OF SPIN-SPIN COUPLING BY TWO-DIMENSIONAL NMR
BAX, A
FREEMAN, R
[J]. JOURNAL OF MAGNETIC RESONANCE, 1981, 44 (03) : 542 - 561
[5] BREITMAIER E, 1987, CARBON 13 NMR SPECTR, P80
[6] DOPKE W, 1977, HETEROCYCLES, V6, P551
[7] H-1 AND C-13 NMR ANALYSIS OF LYCORINE AND ALPHA-DIHYDROLYCORINE
EVIDENTE, A
CICALA, MR
GIUDICIANNI, I
RANDAZZO, G
RICCIO, R
[J]. PHYTOCHEMISTRY, 1983, 22 (02) : 581 - 584
[8] ALKALOIDS OF AMARYLLIDACEAE .12. AROMATIC OXYGENATION PATTERNS AND STEREOCHEMISTRY OF SOME TRIOXYARYL ALKALOIDS OF HEMIACETAL AND LACTONE SERIES
HAWKSWORTH, WA
JEFFS, PW
TIDD, BK
TOUBE, TP
[J]. JOURNAL OF THE CHEMICAL SOCIETY, 1965, (MAR): : 1991 - +
[9] IBUKA TOSHIRO, 1966, TETRAHEDRON LETT, V39, P4745
[10] NOBILISINE, A NEW ALKALOID FROM CLIVIA-NOBILIS
JEFFS, PW
MUELLER, L
ABOUDONIA, AH
ELDIN, AAS
CAMPAU, D
[J]. JOURNAL OF NATURAL PRODUCTS, 1988, 51 (03): : 549 - 554

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