Are anti-beta2-Glycoprotein-I antibodies markers for recurrent pregnancy loss in lupus anticoagulant/anticardiolipin seronegative women?

被引：12

作者：

Alijotas-Reig, Jaume ^{[1
,2
,3
]}

Casellas-Caro, Manel ^{[4
]}

Ferrer-Oliveras, Raquel ^{[4
]}

Llurba-Olive, Elisa ^{[4
]}

Hermosilla, Eduard ^{[5
]}

Vilardell-Tarres, Miquel ^{[1
,2
]}

Cabero-Roura, Lluis ^{[4
]}

机构：

[1] Hosp Univ Vall Hebron, Dept Internal Med 1, Syst Autoimmune Dis Unit, Barcelona, Spain

[2] Univ Autonoma Barcelona, Dept Med, E-08193 Barcelona, Spain

[3] Univ Autonoma Barcelona, Inst Univ Dexeus, E-08193 Barcelona, Spain

[4] Univ Autonoma Barcelona, Hosp Univ Vall Hebron, Dept Obstet, E-08193 Barcelona, Spain

[5] Univ Autonoma Barcelona, Hosp Univ Vall Hebron, Dept Prevent Med Epidemiol & Stat, E-08193 Barcelona, Spain

来源：

AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY | 2008年 / 60卷 / 03期

关键词：

anti-cofactor syndrome; antiphospholipid antibodies; antiphospholipid syndrome; anti-beta(2)GPI antibodies; recurrent miscarriage; treatment;

D O I：

10.1111/j.1600-0897.2008.00618.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Problem Anti-beta(2)-Glicoprotein-1 antibodies (anti-beta(2)GPI-ab) have been related to recurrent miscarriage (RM) with conflicting results. The aim was to evaluate the role of anti-beta(2)-GPI-ab as unique biological marker in RM related to antiphospholipid (aPL). Method of study A cohort study that included 59 cases, divided in two groups, was designed: group 1 comprised 43 pregnant women with 'obstetric' antiphospholipid syndrome (APS) and group 2 included 16 cases with similar complaints but only having repeatedly anti-beta(2)-GPI-ab. Previous thrombosis and/or inherited thrombophilia were excluded. Lupus anticoagulant, anticardiolipin antibodies (aCA), anti-beta(2)-GPI-ab, and other autoantibodies were analyzed. Miscarriages, premature births, pre-eclampsia, live births, placental and systemic thromboses were studied. Results No differences in previous obstetric complications were detected (P = 1.00-0.164). After the treatment, differences in number of obstetric complications were not seen (P = 1.00). Live births were similar in two groups (88.4% and 93.7%; P = 1.00). Placental thrombosis was equal in both groups, 93.3% versus 80% (P = 1.00). Conclusion These results suggest that anti-beta(2)-GPI-ab may be considered a biological marker for obstetric APS.

引用

页码：229 / 237

页数：9

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