An easy stereospecific synthesis of 1-amino-2,5-anhydro-1-deoxy-D-mannitol and arylamino derivatives

被引：22

作者：

Claustre, S

Bringaud, F

Azéma, L

Baron, R

Périé, J

Willson, M ^{[1
]}

机构：

[1] Univ Toulouse 3, Grp Chim Organ Biol, CNRS, UMR 5623, F-31062 Toulouse, France

[2] Univ Bordeaux 2, Lab Immunol & Biol Mol & Parasites Protozoaires, CNRS, UPRESA 5016, F-33076 Bordeaux, France

来源：

CARBOHYDRATE RESEARCH | 1999年 / 315卷 / 3-4期

关键词：

1-amino-2,5-anhydro-1-deoxy-D-mannitol; 2,5-anhydro-1-arylamino-1-deoxy-D-mannitol derivatives; Trypanosoma brucei hexoses transporter (THT1);

D O I：

10.1016/S0008-6215(99)00040-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

1-Amino-2,5-anhydro-1-deoxy-D-mannitol and a series of arylamino derivatives were prepared by nitrous acid deamination of 2-amino-2-deoxy-D-glucose and subsequent reductive amination of the resulting 2,5-anhydro-D-mannose. Some of these compounds showed an enhanced affinity for the hexose transporter of Trypanosoma brucei as compared to D-fructose. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：339 / 344

页数：6

共 13 条

[1] CYANOHYDRIDOBORATE ANION AS A SELECTIVE REDUCING AGENT [J].