Non-signaling chemokine receptors:: Mechanism of action and role in vivo

被引：8

作者：

Bonecchi, Raffaella ^{[1
,2
]}

Borroni, Elena M. ^{[2
]}

Savino, Benedetta ^{[1
,2
]}

Buracchi, Chiara ^{[2
]}

Mantovani, Alberto ^{[1
,2
]}

Locati, Massimo ^{[1
,2
]}

机构：

[1] Univ Milan, Ist Patol Gen, I-20133 Milan, Italy

[2] IRCCS, Ist Clin Humanitas, I-20089 Milan, Italy

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2008年 / 198卷 / 1-2期

关键词：

chemokine; decoy receptor; scavenger receptor; inflammation;

D O I：

10.1016/j.jneuroim.2008.04.018

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Cell migration is fundamental for numerous biological processes and is critical for the pathogenesis of several diseases. Chemokines represent the main class of mediators providing cell directional migration and several levels of regulation of their function have been identified. A subfamily of chemokine receptors not able to transduce chemotactic signals plays an important role in the control of chemokine concentrations through binding, internalization and degradation of chemotactic factors. Here we review in vitro and in vivo evidences indicating that these 'silent' chemokine receptors represent a strategy to regulate innate and adaptive immunity. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：14 / 19

页数：6

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