Neuroscience: THE PLAQUE PLAN

被引：44

作者：

Abbott, Alison

机构：

来源：

NATURE | 2008年 / 456卷 / 7219期

关键词：

D O I：

10.1038/456161a

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 [理学]; 0710 [生物学]; 09 [农学];

摘要：

Neuroscientists are pretty sure they know what causes Alzheimer's disease, but their theory has not yet given rise to effective drugs. Alison Abbott asks what's wrong.

引用

页码：161 / 164

页数：4

共 7 条

[1]

Research criteria for the diagnosis of Alzheimer"s disease: revising the NINCDS-ADRDA criteria [J].

Dubois, Bruno ;

Feldman, Howard H. ;

Jacova, Claudia ;

Dekosky, Steven T. ;

Barberger-Gateau, Pascale ;

Cummings, Jeffrey ;

Delocourte, Andre ;

Galasko, Douglas ;

Gauthier, Serge ;

Jicha, Gregory ;

Meguro, Kenichi ;

O'Brien, John ;

Pasquier, Florence ;

Robert, Philippe ;

Rossor, Martin ;

Solloway, Steven ;

Stern, Yaakov ;

Visser, Pieter J. ;

Scheltens, Philip .

LANCET NEUROLOGY, 2007, 6 (08) :734-746

[2]

Global prevalence of dementia: a Delphi consensus study [J].

Ferri, CP ;

Prince, M ;

Brayne, C ;

Brodaty, H ;

Fratiglioni, L ;

Ganguli, M ;

Hall, K ;

Hasegawa, K ;

Hendrie, H ;

Huang, YQ ;

Jorm, A ;

Mathers, C ;

Menezes, PR ;

Rimmer, E ;

Scazufca, M .

LANCET, 2005, 366 (9503) :2112-2117

[3]

Long-term effects of Aβ42 immunisation in Alzheimer's disease:: follow-up of a randomised, placebo-controlled phase I trial [J].

Holmes, Clive ;

Boche, Delphine ;

Wilkinson, David ;

Yadegarfar, Ghasem ;

Hopkins, Vivienne ;

Bayer, Anthony ;

Jones, Roy W. ;

Bullock, Roger ;

Love, Seth ;

Neal, James W. ;

Zotova, Elina ;

Nicoll, James A. R. .

LANCET, 2008, 372 (9634) :216-223

[4]

Post-mortem correlates of in vivo PiB-PET amyloid imaging in a typical case of Alzheimer's disease [J].

Ikonomovic, Milos D. ;

Klunk, William E. ;

Abrahamson, Eric E. ;

Mathis, Chester A. ;

Price, Julie C. ;

Tsopelas, Nicholas D. ;

Lopresti, Brian J. ;

Ziolko, Scott ;

Bi, Wenzhu ;

Paljug, William R. ;

Debnath, Manik L. ;

Hope, Caroline E. ;

Isanski, Barbara A. ;

Hamilton, Ronald L. ;

DeKosky, Steven T. .

BRAIN, 2008, 131 :1630-1645

[5]

Drug markers questioned [J].

Ledford, Heidi .

NATURE, 2008, 452 (7187) :510-511

[6]

Aβ-42 deposition precedes other changes in PS-1 Alzheimer's disease [J].

Lippa, CF ;

Nee, LE ;

Mori, H ;

St George-Hyslop, P .

LANCET, 1998, 352 (9134) :1117-1118

[7]

Reducing endogenous tau ameliorates amyloid β-induced deficits in an Alzheimer's disease mouse model [J].

Roberson, Erik D. ;

Scearce-Levie, Kimberly ;

Palop, Jorge J. ;

Yan, Fengrong ;

Cheng, Irene H. ;

Wu, Tiffany ;

Gerstein, Hilary ;

Yu, Gui-Qiu ;

Mucke, Lennart .

SCIENCE, 2007, 316 (5825) :750-754

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