Superficial siderosis - A potential diagnostic marker of cerebral amyloid angiopathy in Alzheimer disease

被引：50

作者：

Feldman, Howard H. ^{[1
]}

Maia, Luis F. ^{[4
]}

Mackenzie, Ian R. A. ^{[2
]}

Forster, Bruce B. ^{[3
]}

Martzke, Jeff ^{[1
]}

Woolfenden, Andrew ^{[1
]}

机构：

[1] Univ British Columbia, Div Neurol, Vancouver, BC V5Z 1M9, Canada

[2] Univ British Columbia, Dept Med, Div Neuropathol, Vancouver, BC V5Z 1M9, Canada

[3] Univ British Columbia, Dept Pathol, Dept Radiol, Vancouver, BC V5Z 1M9, Canada

[4] Hosp Geral Santo Antonio, Dept Neurol, Oporto, Portugal

来源：

STROKE | 2008年 / 39卷 / 10期

关键词：

Alzheimer disease; cerebral amyloid angiopathy; superficial siderosis;

D O I：

10.1161/STROKEAHA.107.510826

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background and Purpose - Superficial siderosis of the central nervous system results from chronic bleeding in the superficial layers of the cortex and spinal cord. In cerebral amyloid angiopathy (CAA), there is amyloid deposition in meningeal and meningo-cortical arteries and capillaries, predisposing them to rupture. CAA is frequently associated with Alzheimer disease (AD). Methods and Results - We report a series of 3 AD patients with MRI evidence of superficial siderosis. Two had neuropathological examination confirming superficial siderosis, AD, and CAA. Conclusions - Superficial siderosis should be recognized within the spectrum of AD with CAA and considered as a possible antemortem diagnostic feature.

引用

页码：2894 / 2897

页数：4

共 11 条

[1] Alzheimer's disease pathology influences severity and topographical distribution of cerebral amyloid angiopathy [J].

Attems, J ;

Jellinger, KA ;

Lintner, F .

ACTA NEUROPATHOLOGICA, 2005, 110 (03) :222-231

[2] Recurrent subarachnoid hemorrhage associated with a new transthyretin variant (Gly53Glu) [J].

Ellie, E ;

Camou, F ;

Vital, A ;

Rummens, C ;

Grateau, G ;

Delpech, M ;

Valleix, S .

NEUROLOGY, 2001, 57 (01) :135-137

[3] SUPERFICIAL SIDEROSIS OF THE CENTRAL-NERVOUS-SYSTEM [J].

FEARNLEY, JM ;

STEVENS, JM ;

RUDGE, P .

BRAIN, 1995, 118 :1051-1066

[4] Cerebral amyloid angiopathy - Prospects for clinical diagnosis and treatment [J].

Greenberg, SM .

NEUROLOGY, 1998, 51 (03) :690-694

[5]

GREENE JD, 1996, ARCH NEUROL-CHICAGO, V10, P1072

[6] Clinical diagnosis of cerebral amyloid angiopathy: Validation of the Boston Criteria [J].

Knudsen, KA ;

Rosand, J ;

Karluk, D ;

Greenberg, SM .

NEUROLOGY, 2001, 56 (04) :537-539

[7] Transthyretin amyloidosis and superficial siderosis of the CNS [J].

Mascalchi, M ;

Salvi, FP ;

Pirini, MG ;

D'Errico, A ;

Ferlini, A ;

Lolli, F ;

Plasmati, R ;

Tessa, C ;

Villari, N ;

Tassinari, CA .

NEUROLOGY, 1999, 53 (07) :1498-1503

[8] Transient neurologic symptoms related to cerebral amyloid angiopathy:: Usefulness of T2*-weighted imaging [J].

Roch, JA ;

Nighoghossian, N ;

Hermier, M ;

Cakmak, S ;

Picot, M ;

Honnorat, J ;

Derex, L ;

Trouillas, P .

CEREBROVASCULAR DISEASES, 2005, 20 (05) :412-414

[9] Cognitive and social impairments in patients with superficial siderosis [J].

van Harskamp, NJ ;

Rudge, P ;

Cipolotti, L .

BRAIN, 2005, 128 :1082-1092

[10] CEREBRAL AMYLOID ANGIOPATHY - A CRITICAL-REVIEW [J].

VINTERS, HV .

STROKE, 1987, 18 (02) :311-324

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