Influence of pore size of MCM-41 matrices on drug delivery rate

被引:503
作者
Horcajada, P [1 ]
Rámila, A [1 ]
Pérez-Pariente, J [1 ]
Vallet-Regí, M [1 ]
机构
[1] Univ Complutense Madrid, Fac Farm, Dept Quim Inorgan & Bioinorgan, Madrid 28040, Spain
关键词
MCM-41; drug delivery; mesoporous; pore size; release rate;
D O I
10.1016/j.micromeso.2003.12.012
中图分类号
O69 [应用化学];
学科分类号
081704 ;
摘要
The influence of pore size of MCM-41 materials on drug delivery rate has been studied. In order to achieve this objective, small pore size MCM-41 materials have been synthesised from mixtures of two different alkyltrimethylammonium surfactants with chain length of 8 and 10 carbon atoms. The analgesic ibuprofen was introduced into the pore channels and its delivery to the media has been measured and compared with the delivery from bigger pore-sized MCM-41 obtained from surfactants of 12 and 16 atoms of carbon. This study has revealed that the delivery rate of ibuprofen in a simulating body fluid solution decreases as the pore size decreases in the range of 3.6-2.5 nm. (C) 2003 Elsevier Inc. All rights reserved.
引用
收藏
页码:105 / 109
页数:5
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