Influence of pore size of MCM-41 matrices on drug delivery rate

被引：503

作者：

Horcajada, P ^{[1
]}

Rámila, A ^{[1
]}

Pérez-Pariente, J ^{[1
]}

Vallet-Regí, M ^{[1
]}

机构：

[1] Univ Complutense Madrid, Fac Farm, Dept Quim Inorgan & Bioinorgan, Madrid 28040, Spain

来源：

MICROPOROUS AND MESOPOROUS MATERIALS | 2004年 / 68卷 / 1-3期

关键词：

MCM-41; drug delivery; mesoporous; pore size; release rate;

D O I：

10.1016/j.micromeso.2003.12.012

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The influence of pore size of MCM-41 materials on drug delivery rate has been studied. In order to achieve this objective, small pore size MCM-41 materials have been synthesised from mixtures of two different alkyltrimethylammonium surfactants with chain length of 8 and 10 carbon atoms. The analgesic ibuprofen was introduced into the pore channels and its delivery to the media has been measured and compared with the delivery from bigger pore-sized MCM-41 obtained from surfactants of 12 and 16 atoms of carbon. This study has revealed that the delivery rate of ibuprofen in a simulating body fluid solution decreases as the pore size decreases in the range of 3.6-2.5 nm. (C) 2003 Elsevier Inc. All rights reserved.

引用

页码：105 / 109

页数：5

共 14 条

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