Body fluid biomarkers in multiple sclerosis

被引：201

作者：

Comabella, Manuel ^{[1
]}

Montalban, Xavier ^{[1
]}

机构：

[1] Hosp Univ Vall dHebron, Ctr Esclerosi Multiple Catalunya, Dept Neurol & Neuroimmunol, Cemcat, Barcelona 08035, Spain

来源：

LANCET NEUROLOGY | 2014年 / 13卷 / 01期

关键词：

INTERFERON-BETA THERAPY; ANTI-NATALIZUMAB ANTIBODIES; MYELIN BASIC-PROTEIN; EPSTEIN-BARR-VIRUS; CLINICALLY ISOLATED SYNDROME; NITRIC-OXIDE METABOLITES; TUMOR-NECROSIS-FACTOR; FREE LIGHT-CHAINS; CEREBROSPINAL-FLUID; NEUROMYELITIS-OPTICA;

D O I：

10.1016/S1474-4422(13)70233-3

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

Biomarkers can be thought of as multifaceted indicators of healthy status or of pathological disorders. The study of multiple sclerosis can benefit from the use of biomarkers because of the disease's inherent heterogeneity. Biomarkers in multiple sclerosis might assist with diagnosis, prediction of disease course, or identification of response outcome to treatments. Despite the need for biomarkers and extensive research to identify them, validation and clinical application of biomarkers is still an unmet need in multiple sclerosis, and large gaps remain between exploratory biomarkers proposed in many studies, validated biomarkers, and biomarkers that are integrated into routine clinical practice.

引用

页码：113 / 126

页数：14

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