Factors associated with increased prevalence of human papillomavirus infection in a cohort of HIV-Infected Brazilian women

被引:48
作者
Grinsztejn, Beatriz [1 ]
Veloso, Valdilea Goncalves [1 ]
Levi, Jose Eduardo [2 ]
Velasque, Luciane [1 ]
Luz, Paula Mendes [1 ]
Friedman, Ruth Khalili [1 ]
Andrade, Angela Cristina [1 ]
Moreira, Ronaldo Ismerio [1 ]
Russomano, Fabio [3 ]
Pilotto, Jose Henrique [1 ]
Bastos, Francisco Inacio [4 ]
Palefsky, Joel [5 ]
机构
[1] Fundacao Oswaldo Cruz, Inst Pesquisas Clin Evandro Chagas, BR-21045900 Rio De Janeiro, Brazil
[2] Univ Sao Paulo, Inst Trop Med, Virol Lab, Sao Paulo, Brazil
[3] Fundacao Oswaldo Cruz, IFF, BR-21045900 Rio De Janeiro, Brazil
[4] Fundacao Oswaldo Cruz, ICICT, BR-21045900 Rio De Janeiro, Brazil
[5] Univ Calif San Francisco, San Francisco, CA 94143 USA
关键词
Human papillomavirus; Human immunodeficiency virus; Evandro Chagas Research Institute cohort; Prevalence ratio; Brazil; HUMAN-IMMUNODEFICIENCY-VIRUS; CERVICAL INTRAEPITHELIAL NEOPLASIA; RIO-DE-JANEIRO; RISK-FACTORS; GENITAL WARTS; HPV INFECTION; DNA DETECTION; CANCER; ABNORMALITIES; EPIDEMIOLOGY;
D O I
10.1016/j.ijid.2008.03.031
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Objectives: Human papillomavirus (HPV) infection is a major risk factor for cervical disease. Using baseline data from the HIV-infected cohort of Evandro Chagas Clinical Research Institute at Fiocruz, Rio de Janeiro, Brazil, factors associated with an increased prevalence of HPV were assessed. Methods: Samples from 634 HIV-infected women were tested for the presence of HPV infection using hybrid capture 11 and polymerase chain reaction. Prevalence ratios (PR) were estimated using Poisson regression analysis with robust variance. Results: The overall prevalence of HPV infection was 48%, of which 94% were infected with a high-risk HPV. In multivariate analysis, factors independently associated with infection with high-risk HPV type were: younger age (<30 years of age; PR 1.5, 95% confidence interval (CI) 1.1-2.1), current or prior drug use (PR 1.3, 95% CI 1.0-1.6), self-reported history of HPV infection (PR 1.2, 95% CI 0.96-1.6), condom use in the last sexual intercourse (PR 1.3, 95% CI 1.1-1.7), and nadir CD4+ T-cell count <100 cells/mm(3) (PR 1.6, 95% CI 1.2-2.1). Conclusions: The estimated prevalence of high-risk HPV-infection among HIV-infected women from Rio de Janeiro, Brazil, was high. Close monitoring of HPV-related effects is warranted in all HIV-infected women, in particular those of younger age and advanced immunosuppression. (C) 2008 International Society for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码:72 / 80
页数:9
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