Exercise intensity influences cell injury in rat hippocampal slices exposed to oxygen and glucose deprivation

被引：56

作者：

Scopel, Denise

Fochesatto, Cintia

Cimarosti, Helena

Rabbo, Maristela

Bello-Klein, Adriane

Salbego, Christianne

Netto, Carlos Alexandre

Siqueira, Ionara Rodrigues

机构：

[1] Univ Fed Rio Grande Sul, Dept Farmacol, BR-90050170 Porto Alegre, RS, Brazil

[2] Univ Fed Rio Grande Sul, Dept Fisiol, Porto Alegre, RS, Brazil

来源：

BRAIN RESEARCH BULLETIN | 2006年 / 71卷 / 1-3期

关键词：

exercise; susceptibility to ischemia; oxygen and glucose deprivation; hippocampal slices;

D O I：

10.1016/j.brainresbull.2006.08.011

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We evaluated the effects of two levels of daily forced exercise intensity (moderate and high) in the treadmill over cell susceptibility to oxygen and glucose deprivation (OGD) in hippocampal slices from Wistar rats. Moderate exercise decreased lactate dehydrogenase (LDH) release after OGD, while a significant increase in LDH release was observed in the high intensity group submitted to OGD. Our data corroborate the hypothesis that higher training intensity exacerbates brain damage, while a moderate intensity reduces the injury caused by in vitro ischemia. (c) 2006 Elsevier Inc. All rights reserved.

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收藏

页码：155 / 159

页数：5

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