The crystal structure of human rac1, a member of the rho-family complexed with a GTP analogue

被引：191

作者：

Hirshberg, M ^{[1
]}

Stockley, RW ^{[1
]}

Dodson, G ^{[1
]}

Webb, MR ^{[1
]}

机构：

[1] NATL INST MED RES, DIV PHYS BIOCHEM, LONDON NW7 1AA, ENGLAND

来源：

NATURE STRUCTURAL BIOLOGY | 1997年 / 4卷 / 02期

关键词：

D O I：

10.1038/nsb0297-147

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The crystal structure of human rac1, a member of the rho family of small C-proteins. complexed with the nonhydrolysable GTP analogue, guanosine-5'-(beta gamma-imino)triphosphate (GMPPNP), has been determined by X-ray analysis at a resolution of 1.38 Angstrom. Comparison with the structure of H-ras indicates that rac1 has an extra alpha-helical domain that is characteristic of the rho G proteins, and may be involved in the signalling pathway of this family.

引用

页码：147 / 152

页数：6

共 25 条

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