Stereoselective syntheses and evaluation of compounds in the 8-desmethylepothilone A series: Some surprising observations regarding their chemical and biological properties

被引:42
作者
Balog, A
Bertinato, P
Su, DS
Meng, DF
Sorensen, E
Danishefsky, SJ
Zheng, YH
Chou, TC
He, LE
Horwitz, SB
机构
[1] SLOAN KETTERING INST CANC RES,BIOORGAN CHEM LAB,NEW YORK,NY 10021
[2] SLOAN KETTERING INST CANC RES,BIOCHEM PHARMACOL LAB,NEW YORK,NY 10021
[3] COLUMBIA UNIV,DEPT CHEM,NEW YORK,NY 10027
[4] YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT MOL PHARMACOL,BRONX,NY 10461
关键词
D O I
10.1016/S0040-4039(97)00931-3
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The title compounds have been synthesized in a convergent way by recourse to a Weller type dianion construction. (C) 1997 Elsevier Science Ltd.
引用
收藏
页码:4529 / 4532
页数:4
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