Quantitative Architectural Analysis: A New Approach to Cortical Mapping

被引：40

作者：

Schleicher, Axel ^{[1
]}

Morosan, Patricia ^{[2
]}

Amunts, Katrin ^{[2
,3
,4
]}

Zilles, Karl ^{[1
,4
,5
]}

机构：

[1] Univ Dusseldorf, C&O Vogt Inst Brain Res, D-40225 Dusseldorf, Germany

[2] Forschungszentrum Julich, Inst Neurosci & Med, INM 1, D-52425 Julich, Germany

[3] Rhein Westfal TH Aachen, Dept Psychiat & Psychotherapy, D-52074 Aachen, Germany

[4] Rhein Westfal TH Aachen, JARA, D-52074 Aachen, Germany

[5] Forschungszentrum Julich, INM 2, Inst Neurosci & Med, D-52425 Julich, Germany

来源：

JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS | 2009年 / 39卷 / 11期

关键词：

Cytoarchitecture; Gray level index; Cortical area; Border detection; Brain mapping; HUMAN CEREBRAL-CORTEX; AUTOMATED IMAGE-ANALYSIS; PRIMARY MOTOR CORTEX; GREY LEVEL INDEX; CINGULATE CORTEX; NERVOUS-TISSUE; AREAL PATTERN; 3-DIMENSIONAL RECONSTRUCTION; DISTURBED CYTOARCHITECTURE; STRUCTURAL INHOMOGENEITIES;

D O I：

10.1007/s10803-009-0790-8

中图分类号：

B844 [发展心理学（人类心理学）];

学科分类号：

040202 ;

摘要：

Results from functional imaging studies are often still interpreted using the classical architectonic brain maps of Brodmann and his successors. One obvious weakness in traditional, architectural mapping is the subjective nature of localizing borders between cortical areas by means of a purely visual, microscopical examination of histological specimens. To overcome this limitation, objective mapping procedures based on quantitative cytoarchitecture have been generated. As a result, new maps for various species including man were established. In our contribution, principles of quantitative cytoarchitecture and algorithm-based cortical mapping are described for a cytoarchitectural parcellation of the human auditory cortex. Defining cortical borders based on quantified changes in cortical lamination is the decisive step towards a novel, highly improved probabilistic brain atlas.

引用

页码：1568 / 1581

页数：14

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