Lack of Glutathione Peroxidase 1 Accelerates Cardiac-Specific Hypertrophy and Dysfunction in Angiotensin II Hypertension
被引:58
作者:
Ardanaz, Noelia
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Henry Ford Hosp, Dept Med, Hypertens & Vasc Res Div, Detroit, MI 48202 USAUniv Pittsburgh, Sch Med, Dept Pharmacol & Chem Biol, Pittsburgh, PA 15261 USA
Ardanaz, Noelia
[3
]
Yang, Xiao-Ping
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Henry Ford Hosp, Dept Med, Hypertens & Vasc Res Div, Detroit, MI 48202 USAUniv Pittsburgh, Sch Med, Dept Pharmacol & Chem Biol, Pittsburgh, PA 15261 USA
Yang, Xiao-Ping
[3
]
Cifuentes, M. Eugenia
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机构:
Univ Pittsburgh, Sch Med, Dept Pharmacol & Chem Biol, Pittsburgh, PA 15261 USA
Univ Pittsburgh, Sch Med, Vasc Med Inst, Pittsburgh, PA 15261 USAUniv Pittsburgh, Sch Med, Dept Pharmacol & Chem Biol, Pittsburgh, PA 15261 USA
Cifuentes, M. Eugenia
[1
,2
]
Haurani, Mounir J.
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机构:
Henry Ford Hosp, Dept Med, Hypertens & Vasc Res Div, Detroit, MI 48202 USAUniv Pittsburgh, Sch Med, Dept Pharmacol & Chem Biol, Pittsburgh, PA 15261 USA
Haurani, Mounir J.
[3
]
Jackson, Kyle W.
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Henry Ford Hosp, Dept Med, Hypertens & Vasc Res Div, Detroit, MI 48202 USAUniv Pittsburgh, Sch Med, Dept Pharmacol & Chem Biol, Pittsburgh, PA 15261 USA
Jackson, Kyle W.
[3
]
Liao, Tang-Dong
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Henry Ford Hosp, Dept Med, Hypertens & Vasc Res Div, Detroit, MI 48202 USAUniv Pittsburgh, Sch Med, Dept Pharmacol & Chem Biol, Pittsburgh, PA 15261 USA
Liao, Tang-Dong
[3
]
Carretero, Oscar A.
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Henry Ford Hosp, Dept Med, Hypertens & Vasc Res Div, Detroit, MI 48202 USAUniv Pittsburgh, Sch Med, Dept Pharmacol & Chem Biol, Pittsburgh, PA 15261 USA
Carretero, Oscar A.
[3
]
Pagano, Patrick J.
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Univ Pittsburgh, Sch Med, Dept Pharmacol & Chem Biol, Pittsburgh, PA 15261 USA
Univ Pittsburgh, Sch Med, Vasc Med Inst, Pittsburgh, PA 15261 USAUniv Pittsburgh, Sch Med, Dept Pharmacol & Chem Biol, Pittsburgh, PA 15261 USA
Pagano, Patrick J.
[1
,2
]
机构:
[1] Univ Pittsburgh, Sch Med, Dept Pharmacol & Chem Biol, Pittsburgh, PA 15261 USA
[2] Univ Pittsburgh, Sch Med, Vasc Med Inst, Pittsburgh, PA 15261 USA
[3] Henry Ford Hosp, Dept Med, Hypertens & Vasc Res Div, Detroit, MI 48202 USA
Glutathione peroxidase 1 (Gpx1) plays an important role in cellular defense by converting hydrogen peroxide and organic hydroperoxides to nonreactive products, and Gpx1(-/-) mice, which are characterized by reduced tissue glutathione peroxidase activity, are known to exhibit enhanced oxidative stress. Peroxides participate in tissue injury, as well as the hypertrophy of cultured cells, yet the role of Gpx1 to prevent end organ damage in cardiovascular tissue is not clear. We postulated that Gpx1 deletion would potentiate both aortic and cardiac hypertrophy, as well as mean arterial blood pressure, in response to angiotensin II (AngII). Our results show that short-term AngII markedly increased left ventricular mass, myocyte cross-sectional area, and interventricular septum thickness and decreased shortening fraction in Gpx1(-/-) mice as compared with wild-type animals. On the other hand, AngII resulted in a similar increase in mean arterial blood pressure in wild-type and Gpx1(-/-) mice. Collagen deposition increased in response to AngII, but no differences were found between strains. Vascular hypertrophy increased to the same extent in Gpx1(-/-) and wild-type mice. Collectively, our results indicate that Gpx1 deficiency accelerates cardiac hypertrophy and dysfunction but has no effect on vascular hypertrophy and mean arterial blood pressure and suggest a major role for Gpx1 in cardiac dysfunction in AngII-dependent hypertension. (Hypertension. 2010;55:116-123.)
机构:
Univ Iowa, Carver Coll Med, Dept Internal Med, Div Cardiovasc Med, Iowa City, IA 52242 USAUniv Iowa, Carver Coll Med, Dept Internal Med, Div Cardiovasc Med, Iowa City, IA 52242 USA
Chrissobolis, Sophocles
;
Didion, Sean P.
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Univ Iowa, Carver Coll Med, Dept Internal Med, Div Cardiovasc Med, Iowa City, IA 52242 USAUniv Iowa, Carver Coll Med, Dept Internal Med, Div Cardiovasc Med, Iowa City, IA 52242 USA
Didion, Sean P.
;
Kinzenbaw, Dale A.
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Univ Iowa, Carver Coll Med, Dept Internal Med, Div Cardiovasc Med, Iowa City, IA 52242 USAUniv Iowa, Carver Coll Med, Dept Internal Med, Div Cardiovasc Med, Iowa City, IA 52242 USA
Kinzenbaw, Dale A.
;
Schrader, Laura I.
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Univ Iowa, Carver Coll Med, Dept Internal Med, Div Cardiovasc Med, Iowa City, IA 52242 USAUniv Iowa, Carver Coll Med, Dept Internal Med, Div Cardiovasc Med, Iowa City, IA 52242 USA
Schrader, Laura I.
;
Dayal, Sanjana
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Univ Iowa, Carver Coll Med, Dept Internal Med, Div Cardiovasc Med, Iowa City, IA 52242 USAUniv Iowa, Carver Coll Med, Dept Internal Med, Div Cardiovasc Med, Iowa City, IA 52242 USA
Dayal, Sanjana
;
Lentz, Steven R.
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Univ Iowa, Carver Coll Med, Dept Internal Med, Div Cardiovasc Med, Iowa City, IA 52242 USA
Vet Affairs Med Ctr, Iowa City, IA 52242 USAUniv Iowa, Carver Coll Med, Dept Internal Med, Div Cardiovasc Med, Iowa City, IA 52242 USA
Lentz, Steven R.
;
Faraci, Frank M.
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机构:
Univ Iowa, Carver Coll Med, Dept Internal Med, Div Cardiovasc Med, Iowa City, IA 52242 USA
Univ Iowa, Carver Coll Med, Dept Pharmacol, Iowa City, IA 52242 USAUniv Iowa, Carver Coll Med, Dept Internal Med, Div Cardiovasc Med, Iowa City, IA 52242 USA
机构:Univ Alberta, Heritage Med Res Ctr 4 62, Dept Paediat, Cardiovasc Res Grp, Edmonton, AB T6G 2S2, Canada
Ferdinandy, P
;
Danial, H
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机构:Univ Alberta, Heritage Med Res Ctr 4 62, Dept Paediat, Cardiovasc Res Grp, Edmonton, AB T6G 2S2, Canada
Danial, H
;
Ambrus, I
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机构:Univ Alberta, Heritage Med Res Ctr 4 62, Dept Paediat, Cardiovasc Res Grp, Edmonton, AB T6G 2S2, Canada
Ambrus, I
;
Rothery, RA
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机构:Univ Alberta, Heritage Med Res Ctr 4 62, Dept Paediat, Cardiovasc Res Grp, Edmonton, AB T6G 2S2, Canada
Rothery, RA
;
Schulz, R
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机构:
Univ Alberta, Heritage Med Res Ctr 4 62, Dept Paediat, Cardiovasc Res Grp, Edmonton, AB T6G 2S2, CanadaUniv Alberta, Heritage Med Res Ctr 4 62, Dept Paediat, Cardiovasc Res Grp, Edmonton, AB T6G 2S2, Canada
机构:
Univ Iowa, Carver Coll Med, Dept Internal Med, Div Cardiovasc Med, Iowa City, IA 52242 USAUniv Iowa, Carver Coll Med, Dept Internal Med, Div Cardiovasc Med, Iowa City, IA 52242 USA
Chrissobolis, Sophocles
;
Didion, Sean P.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Carver Coll Med, Dept Internal Med, Div Cardiovasc Med, Iowa City, IA 52242 USAUniv Iowa, Carver Coll Med, Dept Internal Med, Div Cardiovasc Med, Iowa City, IA 52242 USA
Didion, Sean P.
;
Kinzenbaw, Dale A.
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h-index: 0
机构:
Univ Iowa, Carver Coll Med, Dept Internal Med, Div Cardiovasc Med, Iowa City, IA 52242 USAUniv Iowa, Carver Coll Med, Dept Internal Med, Div Cardiovasc Med, Iowa City, IA 52242 USA
Kinzenbaw, Dale A.
;
Schrader, Laura I.
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h-index: 0
机构:
Univ Iowa, Carver Coll Med, Dept Internal Med, Div Cardiovasc Med, Iowa City, IA 52242 USAUniv Iowa, Carver Coll Med, Dept Internal Med, Div Cardiovasc Med, Iowa City, IA 52242 USA
Schrader, Laura I.
;
Dayal, Sanjana
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Carver Coll Med, Dept Internal Med, Div Cardiovasc Med, Iowa City, IA 52242 USAUniv Iowa, Carver Coll Med, Dept Internal Med, Div Cardiovasc Med, Iowa City, IA 52242 USA
Dayal, Sanjana
;
Lentz, Steven R.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Carver Coll Med, Dept Internal Med, Div Cardiovasc Med, Iowa City, IA 52242 USA
Vet Affairs Med Ctr, Iowa City, IA 52242 USAUniv Iowa, Carver Coll Med, Dept Internal Med, Div Cardiovasc Med, Iowa City, IA 52242 USA
Lentz, Steven R.
;
Faraci, Frank M.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Carver Coll Med, Dept Internal Med, Div Cardiovasc Med, Iowa City, IA 52242 USA
Univ Iowa, Carver Coll Med, Dept Pharmacol, Iowa City, IA 52242 USAUniv Iowa, Carver Coll Med, Dept Internal Med, Div Cardiovasc Med, Iowa City, IA 52242 USA
机构:Univ Alberta, Heritage Med Res Ctr 4 62, Dept Paediat, Cardiovasc Res Grp, Edmonton, AB T6G 2S2, Canada
Ferdinandy, P
;
Danial, H
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h-index: 0
机构:Univ Alberta, Heritage Med Res Ctr 4 62, Dept Paediat, Cardiovasc Res Grp, Edmonton, AB T6G 2S2, Canada
Danial, H
;
Ambrus, I
论文数: 0引用数: 0
h-index: 0
机构:Univ Alberta, Heritage Med Res Ctr 4 62, Dept Paediat, Cardiovasc Res Grp, Edmonton, AB T6G 2S2, Canada
Ambrus, I
;
Rothery, RA
论文数: 0引用数: 0
h-index: 0
机构:Univ Alberta, Heritage Med Res Ctr 4 62, Dept Paediat, Cardiovasc Res Grp, Edmonton, AB T6G 2S2, Canada
Rothery, RA
;
Schulz, R
论文数: 0引用数: 0
h-index: 0
机构:
Univ Alberta, Heritage Med Res Ctr 4 62, Dept Paediat, Cardiovasc Res Grp, Edmonton, AB T6G 2S2, CanadaUniv Alberta, Heritage Med Res Ctr 4 62, Dept Paediat, Cardiovasc Res Grp, Edmonton, AB T6G 2S2, Canada