The NLRP3 inflammasome: A sensor of immune danger signals

被引：188

作者：

Cassel, Suzanne L. ^{[1
]}

Joly, Sophie ^{[2
]}

Sutterwala, Fayyaz S. ^{[2
,3
]}

机构：

[1] Univ Iowa, Div Allergy & Immunol, Dept Internal Med, Iowa City, IA 52242 USA

[2] Univ Iowa, Inflammat Program, Dept Internal Med, Iowa City, IA 52242 USA

[3] Univ Iowa, Div Infect Dis, Dept Internal Med, Iowa City, IA 52242 USA

来源：

SEMINARS IN IMMUNOLOGY | 2009年 / 21卷 / 04期

基金：

美国国家卫生研究院;

关键词：

Inflammasome; NLRP3; Caspase-1; Interleukin-1; beta; PATTERN-RECOGNITION RECEPTORS; MUCKLE-WELLS-SYNDROME; NALP3; INFLAMMASOME; INTERLEUKIN-1-BETA RELEASE; DENDRITIC CELLS; URIC-ACID; ACTIVATION; CASPASE-1; INFECTION; SECRETION;

D O I：

10.1016/j.smim.2009.05.002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The innate immune system senses danger signals via evolutionary conserved receptors. The nucleotide-binding domain leucine-rich repeat containing receptor (NLR) family is a group of intracellular receptors that drive a wide variety of inflammatory responses. A number of the NLR family members can form inflammasomes, which are multiprotein complexes that can activate caspase-1 and ultimately lead to the processing and secretion of interleukin (IL)-1 beta, IL-18 and IL-33. One of the best-studied members of the NLR family is NLRP3 for which a number of divergent activators have recently been described. These and other studies examining the NLRP3 inflammasome will be discussed in this review. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：194 / 198

页数：5

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