Stereoselective synthesis of carbocyclic L-4′-fluoro-2′,3′-dideoxyadenosine

被引：23

作者：

Gumina, G ^{[1
]}

Chong, Y ^{[1
]}

Choi, Y ^{[1
]}

Chu, CK ^{[1
]}

机构：

[1] Univ Georgia, Coll Pharm, Dept Pharmaceut & Biomed Sci, Athens, GA 30602 USA

来源：

ORGANIC LETTERS | 2000年 / 2卷 / 09期

关键词：

D O I：

10.1021/ol005665k

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

L-(1'S,3'S)-9-[3-Fluoro-3-(hydroxymethyl)cyclopentan-1-yl]adenine 15 has been synthesized from ester 2, which can be conveniently prepared from 2,3-isopropylidene-D-glyceraldehyde 1 in six steps. The key ring closure has been accomplished through an intramolecular nucleophilic substitution reaction.

引用

页码：1229 / 1231

页数：3

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