Bioavailability of isoflavones

被引:100
作者
Hendrich, S [1 ]
机构
[1] Iowa State Univ, Ames, IA 50011 USA
来源
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES | 2002年 / 777卷 / 1-2期
关键词
reviews; bioavailability; isoflavones;
D O I
10.1016/S1570-0232(02)00347-1
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Isoflavones are disease protective components of soybeans. Isoflavone metabolism and bioavailability are key to understanding their biological effects. Isoflavone glucuronides, dominant biotransformation products in humans that are more hydrophilic than isoflavone aglycones, activate human natural killer cells in vitro but are less toxic to NK cells than the parent aglycones. Gut microbial isoflavone metabolites have also been identified, but remain to be well characterized. Gut transit time (GTT) seems to be a significant determinant of isoflavone bioavailability because women with more rapid GTT (<40 h) experienced 2-3-fold greater absorption of isoflavones than did women with longer GTT (>65 h). Isoflavone metabolism varies a great deal among individuals, thus limiting the quantitative value of urine or plasma isoflavones as biomarkers of soy ingestion. Defining and lessening interindividual variation in isoflavone bioavailability, and characterizing health-related effects of key isoflavone metabolites are likely to be crucial to further understanding of the health benefits of isoflavones. (C) 2002 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:203 / 210
页数:8
相关论文
共 35 条
[1]   ISOTOPE-DILUTION GAS-CHROMATOGRAPHIC MASS-SPECTROMETRIC METHOD FOR THE DETERMINATION OF LIGNANS AND ISOFLAVONOIDS IN HUMAN URINE, INCLUDING IDENTIFICATION OF GENISTEIN [J].
ADLERCREUTZ, H ;
FOTSIS, T ;
BANNWART, C ;
WAHALA, K ;
BRUNOW, G ;
HASE, T .
CLINICA CHIMICA ACTA, 1991, 199 (03) :263-278
[2]   Epidemiology of phytoestrogens [J].
Adlercreutz, M .
BAILLIERES CLINICAL ENDOCRINOLOGY AND METABOLISM, 1998, 12 (04) :605-623
[3]   SOYA - A DIETARY SOURCE OF THE NON-STEROIDAL ESTROGEN EQUOL IN MAN AND ANIMALS [J].
AXELSON, M ;
SJOVALL, J ;
GUSTAFSSON, BE ;
SETCHELL, KDR .
JOURNAL OF ENDOCRINOLOGY, 1984, 102 (01) :49-56
[4]   IDENTIFICATION OF THE ISOFLAVONIC PHYTOESTROGEN DAIDZEIN IN HUMAN-URINE [J].
BANNWART, C ;
FOTSIS, T ;
HEIKKINEN, R ;
ADLERCREUTZ, H .
CLINICA CHIMICA ACTA, 1984, 136 (2-3) :165-172
[5]   Mass spectrometric determination of genistein tissue distribution in diet-exposed Sprague-Dawley rats [J].
Chang, HC ;
Churchwell, MI ;
Delclos, KB ;
Newbold, RR ;
Doerge, DR .
JOURNAL OF NUTRITION, 2000, 130 (08) :1963-1970
[6]   Usual dietary consumption of soy foods and its correlation with the excretion rate of isoflavonoids in overnight urine samples among Chinese women in Shanghai [J].
Chen, Z ;
Zheng, W ;
Custer, LJ ;
Dai, Q ;
Shu, XO ;
Jin, F ;
Franke, AA .
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL, 1999, 33 (01) :82-87
[7]   A randomized trial comparing the effect of casein with that of soy protein containing varying amounts of isoflavones on plasma concentrations of lipids and lipoproteins [J].
Crouse, JR ;
Morgan, T ;
Terry, JG ;
Ellis, J ;
Vitolins, M ;
Burke, GL .
ARCHIVES OF INTERNAL MEDICINE, 1999, 159 (17) :2070-2076
[8]   HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC ASSAY OF ISOFLAVONOIDS AND COUMESTROL FROM HUMAN URINE [J].
FRANKE, AA ;
CUSTER, LJ .
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 1994, 662 (01) :47-60
[9]  
Gamache PH, 1998, P SOC EXP BIOL MED, V217, P274
[10]   Identification of isoflavone metabolites dihydrodaidzein, dihydrogenistein, 6′-OH-O-dma, and cis-4-OH-equol in human urine by gas chromatography-mass spectroscopy using authentic reference compounds [J].
Heinonen, S ;
Wähälä, K ;
Adlercreutz, H .
ANALYTICAL BIOCHEMISTRY, 1999, 274 (02) :211-219