Mit1/Lb9 and Copg2, new members of mouse imprinted genes closely linked to Peg1/Mest

被引：50

作者：

Lee, YJ

Park, CW

Hahn, Y

Park, J

Lee, J

Yun, JH

Hyun, B

Chung, JH ^{[1
]}

机构：

[1] Korea Adv Inst Sci & Technol, Dept Biol Sci, Taejon 305701, South Korea

[2] Korea Res Inst Biosci & Biotechnol, Genet Resources Ctr, Biol Resources Lab, Taejon 306600, South Korea

来源：

FEBS LETTERS | 2000年 / 472卷 / 2-3期

关键词：

imprinting; Peg1/Mest; coatomer protein complex; antisense RNA;

D O I：

10.1016/S0014-5793(00)01461-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two mouse genes, Mit11Lb9 and Copg2, linked to Peg11Mest on mouse chromosome 6, were identified to be imprinted maternally and paternally, respectively. Mit11Lb9 encoding untranslated transcripts resides within the intron 20 of Copg2. The gene is maternally imprinted in adult mouse brain, partially imprinted in other tissues, Copg2 consists of 24 exons within the > 40 kb genomic region, being expressed ubiquitously in mouse tissues with a partial imprinting pattern in embryos, neonates, and adult brain in contrast to maternally imprinted human COPG2, In addition, we identified an antisense transcript of Copg2, Copg2AS, which overlaps 3'-UTRs of Copg2 and Peg11Mest. The Copg2AS transcript is maternally imprinted in embryos, neonates, and adult tissues. (C) 2000 Federation of European Biochemical Societies.

引用

页码：230 / 234

页数：5

共 23 条

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