A small molecule with osteogenesis-inducing activity in multipotent mesenchymal progenitor cells

被引：213

作者：

Wu, X

Ding, S

Ding, Q

Gray, NS

Schultz, PG

机构：

[1] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

[2] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA

[3] Novartis Res Fdn, Genom Inst, San Diego, CA 92121 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2002年 / 124卷 / 49期

关键词：

D O I：

10.1021/ja0283908

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Purmorphamine, which is a 2,6,9-trisubstituted purine compound, was discovered through cell-based high-throughput screening from a heterocycle combinatorial library. It differentiates multipotent mesenchymal progenitor cells into an osteoblast lineage. It will serve as a unique chemical tool to study the molecular mechanisms of osteogenesis of stem cells and bone development. Copyright © 2002 American Chemical Society.

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页码：14520 / 14521

页数：2

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