Convergence of genetic findings for nicotine dependence and smoking related diseases with chromosome 15q24-25

被引：82

作者：

Bierut, Laura Jean ^{[1
]}

机构：

[1] Washington Univ, Sch Med, St Louis, MO 63110 USA

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 2010年 / 31卷 / 01期

关键词：

LUNG-CANCER; GENOME-WIDE; SUSCEPTIBILITY LOCUS; CANDIDATE GENE; 15Q25; LOCUS; RISK; ASSOCIATION; VARIANTS; SMOKERS; CHRNA5-CHRNA3-CHRNB4;

D O I：

10.1016/j.tips.2009.10.004

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Due to the adverse health consequences related to smoking, it is important to understand factors that contribute to nicotine dependence. The most replicated genetic finding for nicotine dependence points to variants on chromosome 15, which includes the alpha 5-alpha 3-beta 4 nicotinic receptor gene cluster. A compelling functional variant is a polymorphism, rs16969968, which alters an amino acid in the alpha 5 nicotinic receptor subunit. Several prominent studies report that the replicated nicotine dependence locus also influences the risk for lung cancer and chronic obstructive pulmonary disease. This represents an exciting convergence of genetic findings, and highlights the potential for research on smoking to inform public health.

引用

页码：46 / 51

页数：6

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