Trastuzumab: A Picky Partner?

被引：3

作者：

McArthur, Heather L. ^{[1
]}

Hudis, Clifford A. ^{[1
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Breast Canc Med Serv, Dept Med, New York, NY 10065 USA

来源：

CLINICAL CANCER RESEARCH | 2009年 / 15卷 / 20期

关键词：

HER2-POSITIVE BREAST-CANCER; ADJUVANT CHEMOTHERAPY; PLUS; PACLITAXEL;

D O I：

10.1158/1078-0432.CCR-09-1917

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Preclinical and clinical models of HER2-positive breast cancer show that human epidermal growth factor receptor 2 (HER2)-targeted therapy with trastuzumab adds significant benefits and modest risks to conventional cytotoxic therapies. Building on this advance will likely depend on elucidation of relevant signaling pathways and mechanisms of action for effective HER2-targeted therapies. (Clin Cancer Res 2009;15(20):6311-3)

引用

页码：6311 / 6313

页数：3

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