An Overview of Chemical Processes That Damage Cellular DNA: Spontaneous Hydrolysis, Alkylation, and Reactions with Radicals

被引：370

作者：

Gates, Kent S. ^{[1
,2
]}

机构：

[1] Univ Missouri, Dept Chem, Columbia, MO 65211 USA

[2] Univ Missouri, Dept Biochem, Columbia, MO 65211 USA

来源：

CHEMICAL RESEARCH IN TOXICOLOGY | 2009年 / 22卷 / 11期

关键词：

INTERSTRAND CROSS-LINKS; CENTER-DOT-DA; APURINIC APYRIMIDINIC SITES; ONE-ELECTRON OXIDATION; ABASIC SITES; CYTOSINE DEAMINATION; TANDEM LESIONS; 2-DEOXYRIBONOLACTONE LESION; DEOXYRIBONUCLEIC-ACID; DIMROTH-REARRANGEMENT;

D O I：

10.1021/tx900242k

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The sequence of heterocyclic bases on the interior of the DNA double helix constitutes the genetic code that drives the operation of all living organisms. With this said, it is not surprising that chemical modification of cellular DNA can have profound biological consequences. Therefore, the organic chemistry of DNA damage is fundamentally important to diverse fields including medicinal chemistry, toxicology, and biotechnology. This review is designed to provide a brief overview of the common types of chemical reactions that lead to DNA damage under physiological conditions.

引用

页码：1747 / 1760

页数：14

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