Uniform surface modification of 3D Bioglass®-based scaffolds with mesoporous silica particles (McM-41) for enhancing drug delivery capability

被引：21

作者：

Boccardi, Elena ^{[1
]}

Philippart, Anahi ^{[1
]}

Juhasz-Bortuzzo, Judith A. ^{[1
]}

Beltran, Ana M. ^{[2
,4
]}

Novajra, Giorgia ^{[3
]}

Vitale-Brovarone, Chiara ^{[3
]}

Spiecker, Erdmann ^{[2
]}

Boccaccini, Aldo R. ^{[1
]}

机构：

[1] Friedrich Alexander Univ Erlangen Nurnberg, Inst Biomat, Dept Mat Sci & Engn, Erlangen, Germany

[2] Friedrich Alexander Univ Erlangen Nurnberg, Dept Mat Sci & Engn, Inst Micro & Nanostruct Res, Ctr Nanoanal & Electron Microscopy CENEM, Erlangen, Germany

[3] Politecn Torino, Inst Mat Phys & Engn, Appl Sci & Technol Dept, Turin, Italy

[4] Univ Seville, CSIC, ICMS, Seville, Spain

来源：

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY | 2015年 / 3卷

关键词：

ordered mesoporosity; silica; MCM-41; bioactive glass; scaffolds; drug release; ibuprofen;

D O I：

10.3389/fbioe.2015.00177

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 090105 [作物生产系统与生态工程];

摘要：

The design and characterization of a new family of multifunctional scaffolds based on bioactive glass (BG) of 45S5 composition for bone tissue engineering and drug delivery applications are presented. These BG-based scaffolds are developed via a replication method of polyurethane packaging foam. In order to increase the therapeutic functionality, the scaffolds were coated with mesoporous silica particles (MCM-41), which act as an in situ drug delivery system. These sub-micron spheres are characterized by large surface area and pore volume with a narrow pore diameter distribution. The solution used for the synthesis of the silica mesoporous particles was designed to obtain a high-ordered mesoporous structure and spherical shape - both are key factors for achieving the desired controlled drug release. The MCM-41 particles were synthesized directly inside the BG-based scaffolds, and the drug-release capability of this combined system was evaluated. Moreover, the effect of MCM-41 particle coating on the bioactivity of the BG-based scaffolds was assessed. The results indicate that it is possible to obtain a multifunctional scaffold system characterized by high and interconnected porosity, high bioactivity, and sustained drug delivery capability.

引用

页数：12

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