Serotonin and human information processing:: an electromyographic study of the effects of fluvoxamine on choice reaction time

被引：16

作者：

Rihet, P

Hasbroucq, T

Blin, O

Possamaï, CA ^{[1
]}

机构：

[1] CNRS, Ctr Rech Neurosci Cognit, Equip Organ Fonct Cortex Cerebral, Marseille, France

[2] CHU Timone, Ctr Pharmacol Clin & Evaluat Therapeut Physiopath, Marseille, France

来源：

NEUROSCIENCE LETTERS | 1999年 / 265卷 / 02期

关键词：

serotonergic systems; fluvoxamine; human information processing; motor processes; choice reaction time; reaction time fractionation;

D O I：

10.1016/S0304-3940(99)00231-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Previous studies have shown that fluvoxamine, an inhibitor of serotonin reuptake, shortens choice reaction time, The present study, was intended to explore this effect by using two complementary approaches: (i) Sternberg's additive factor method, and (ii) the analysis of the electromyographic activity of a prime mover. Eight healthy subjects who received either a sing le oral dose of fluvoxamine (100 mg) or a placebo participated in a choice reaction time experiment in which imperative signal intensity, stimulus-response mapping, and response repertoire were manipulated. Previous results were replicated. Moreover, it was shown that fluvoxamine shortens the interval between prime mover activation and overt response. This supports the hypothesis proposed in a previous study that fluvoxamine affects motor processes. A possible mechanism of this effect is discussed. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：143 / 146

页数：4

共 12 条

[1] WAITING IN READINESS - GATING IN ATTENTION AND MOTOR PREPARATION [J].