Inpatient management of alcohol withdrawal: a practical approach

被引:4
作者
Chabria, Shiven B. [1 ]
机构
[1] Yale Univ, Sch Med, Waterbury Hosp, Dept Internal Med, Waterbury, CT USA
关键词
substance abuse; pharmacology; addiction; pathophysiology; critical care;
D O I
10.22514/SV31.042008.3
中图分类号
R4 [临床医学];
学科分类号
1002 [临床医学]; 100602 [中西医结合临床];
摘要
Alcohol intake contributes directly or indirectly to 15 to 20% of medical problems in primary care or an inpatient setting. It is estimated that approximately 500, 000 episodes of withdrawal will be severe enough to require pharmacologic intervention. The total cost to the United States economy from alcohol abuse was estimated to be $185 billion for 1998. This review attempts to put forth a practical and evidence based approach towards the inpatient management of alcohol withdrawal. Various agents and their pharmacology are described. Strength of evidence regards to efficacy and shorter inpatient stays is examined.
引用
收藏
页码:24 / 29
页数:6
相关论文
共 34 条
[1]
Rapid suppression of alcohol withdrawal syndrome by baclofen [J].
Addolorato, G ;
Caputo, F ;
Capristo, E ;
Janiri, L ;
Bernardi, M ;
Agabio, R ;
Colombo, G ;
Gessa, GL ;
Gasbarrini, G .
AMERICAN JOURNAL OF MEDICINE, 2002, 112 (03) :226-229
[2]
[Anonymous], J CRIT ILLN
[3]
False positives on the clinical institute withdrawal assessment for alcohol-revised: Is this scale appropriate for use in the medically ill? [J].
Bostwick, JM ;
Lapid, MI .
PSYCHOSOMATICS, 2004, 45 (03) :256-261
[4]
Withdrawal from chronic intermittent ethanol treatment changes subunit composition, reduces synaptic function, and decreases behavioral responses to positive allosteric modulators of GABAA receptors [J].
Cagetti, E ;
Liang, J ;
Spigelman, I ;
Olsen, RW .
MOLECULAR PHARMACOLOGY, 2003, 63 (01) :53-64
[5]
Suppression by baclofen of alcohol deprivation effect in Sardinian alcohol-preferring (sP) rats [J].
Colombo, G ;
Serra, S ;
Brunetti, G ;
Vacca, G ;
Carai, MAM ;
Gessa, GL .
DRUG AND ALCOHOL DEPENDENCE, 2003, 70 (01) :105-108
[6]
Successful use of propofol in refractory - Delirium tremens [J].
Coomes, TR ;
Smith, SW .
ANNALS OF EMERGENCY MEDICINE, 1997, 30 (06) :825-828
[7]
Symptom-triggered vs fixed-schedule doses of benzodiazepine for alcohol withdrawal - A randomized treatment trial [J].
Daeppen, JB ;
Gache, P ;
Landry, U ;
Sekera, E ;
Schweizer, V ;
Gloor, S ;
Yersin, B .
ARCHIVES OF INTERNAL MEDICINE, 2002, 162 (10) :1117-1121
[8]
Chlormethiazole potentiates the discriminative stimulus effects of methamphetamine in rats [J].
Gasior, M ;
Witkin, JM ;
Goldberg, SR ;
Munzar, P .
EUROPEAN JOURNAL OF PHARMACOLOGY, 2004, 494 (2-3) :183-189
[9]
Harwood H., 2000, Updating Estimates of the Economic Costs of Alcohol Abuse in the United States: Estimates, Update Methods
[10]
HAWLEY RJ, 1985, ARCH GEN PSYCHIAT, V42, P1056