JAK2 V617F mutation in classic chronic myeloproliferative diseases:: a report on a series of 349 patients

被引:33
作者
Vizmanos, JL [1 ]
Ormazábal, C
Larráyoz, MJ
Cross, NCP
Calasanz, MJ
机构
[1] Univ Navarra, Sch Sci, Dept Genet, E-31080 Pamplona, Spain
[2] Univ Southampton, Div Human Genet, Southampton SO9 5NH, Hants, England
[3] Wessex Reg Genet Lab, Salisbury, Wilts, England
关键词
D O I
10.1038/sj.leu.2404086
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
引用
收藏
页码:534 / 535
页数:3
相关论文
共 10 条
[1]   Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders [J].
Baxter, EJ ;
Scott, LM ;
Campbell, PJ ;
East, C ;
Fourouclas, N ;
Swanton, S ;
Vassiliou, GS ;
Bench, AJ ;
Boyd, EM ;
Curtin, N ;
Scott, MA ;
Erber, WN ;
Green, AR .
LANCET, 2005, 365 (9464) :1054-1061
[2]   The Jak2V617F mutation, PRV-1 overexpression, and EEC formation define a similar cohort of MPD patients [J].
Goerttler, PS ;
Steimle, C ;
März, E ;
Johansson, PL ;
Andreasson, B ;
Griesshammer, M ;
Gisslinger, H ;
Heimpel, H ;
Pahl, HL .
BLOOD, 2005, 106 (08) :2862-2864
[3]   A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera [J].
James, C ;
Ugo, V ;
Le Couédic, JP ;
Staerk, J ;
Delhommeau, F ;
Lacout, C ;
Garçon, L ;
Raslova, H ;
Berger, R ;
Bennaceur-Griscelli, A ;
Villeval, JL ;
Constantinescu, SN ;
Casadevall, N ;
Vainchenker, W .
NATURE, 2005, 434 (7037) :1144-1148
[4]   JAK2 mutation 1849G>T is rare in acute leukemias but can be found in CMML, Philadelphia chromosome-negative CML, and megakaryocytic leukemia [J].
Jelinek, J ;
Oki, Y ;
Gharibyan, V ;
Bueso-Ramos, C ;
Prchal, JT ;
Verstovsek, S ;
Beran, M ;
Estey, E ;
Kantarjian, HM ;
Issa, JPJ .
BLOOD, 2005, 106 (10) :3370-3373
[5]   Widespread occurrence of the JAK2 V617F mutation in chronic myeloproliferative disorders [J].
Jones, AV ;
Kreil, S ;
Zoi, K ;
Waghorn, K ;
Curtis, C ;
Zhang, LY ;
Score, J ;
Seear, R ;
Chase, AJ ;
Grand, FH ;
White, H ;
Zoi, C ;
Loukopoulos, D ;
Terpos, E ;
Vervessou, EC ;
Schultheis, B ;
Emig, M ;
Ernst, T ;
Lengfelder, E ;
Hehlmann, R ;
Hochhaus, A ;
Oscier, D ;
Silver, RT ;
Reiter, A ;
Cross, NCP .
BLOOD, 2005, 106 (06) :2162-2168
[6]   A gain-of-function mutation of JAK2 in myeloproliferative disorders [J].
Kralovics, R ;
Passamonti, F ;
Buser, AS ;
Teo, S ;
Tiedt, R ;
Passweg, JR ;
Tichelli, A ;
Cazzola, M ;
Skoda, RC .
NEW ENGLAND JOURNAL OF MEDICINE, 2005, 352 (17) :1779-1790
[7]   Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis [J].
Levine, RL ;
Wadleigh, M ;
Cools, J ;
Ebert, BL ;
Wernig, G ;
Huntly, BJP ;
Boggon, TJ ;
Wlodarska, L ;
Clark, JJ ;
Moore, S ;
Adelsperger, J ;
Koo, S ;
Lee, JC ;
Gabriel, S ;
Mercher, T ;
D'Andrea, A ;
Fröhling, S ;
Döhner, K ;
Marynen, P ;
Vandenberghe, P ;
Mesa, RA ;
Tefferi, A ;
Griffin, JD ;
Eck, MJ ;
Sellers, WR ;
Meyerson, M ;
Golub, TR ;
Lee, SJ ;
Gilliland, DG .
CANCER CELL, 2005, 7 (04) :387-397
[8]   The JAK2 V617F activating tyrosine kinase mutation is an infrequent event in both "atypical" myeloproliferative disorders and myelodysplastic syndromes [J].
Steensma, DP ;
Dewald, GW ;
Lasho, TL ;
Powell, HL ;
McClure, RF ;
Levine, RL ;
Gilliland, DG ;
Tefferi, A .
BLOOD, 2005, 106 (04) :1207-1209
[9]   JAK2V617F mutation in essential thrombocythaemia:: clinical associations and long-term prognostic relevance [J].
Wolanskyj, AP ;
Lasho, TL ;
Schwager, SM ;
McClure, RF ;
Wadleigh, M ;
Lee, SJ ;
Gilliland, DG ;
Tefferi, A .
BRITISH JOURNAL OF HAEMATOLOGY, 2005, 131 (02) :208-213
[10]   Identification of an acquired JAK2 mutation in Polycythemia vera [J].
Zhao, RX ;
Xing, S ;
Li, Z ;
Fu, XQ ;
Li, QS ;
Krantz, SB ;
Zhao, ZHJ .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (24) :22788-22792