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How many subjects constitute a study?
被引：738
作者：
Friston, KJ
[1
]
Holmes, AP
[1
]
Worsley, KJ
[1
]
机构：
[1] Inst Neurol, Wellcome Dept Cognit Neurol, London WC1N 3BG, England
来源：
关键词：
fMRI;
inference;
fixed and random effects;
conjunctions;
typical;
D O I：
10.1006/nimg.1999.0439
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
In fMRI there are two classes of inference: one aims to make a comment about the "typical" characteristics of a population, and the other about "average" characteristics. The first pertains to studies of normal subjects that try to identify some qualitative aspect of normal functional anatomy. The second class necessarily applies to clinical neuroscience studies that want to make an inference about quantitative differences of a regionally specific nature. The first class of inferences is adequately serviced by conjunction analyses and fixed-effects models with relatively small numbers of subjects. The second requires random-effect analyses and larger cohorts. (C) 1999 Academic Press.
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页码：1 / 5
页数：5
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