Master and commander: continued expression of Prox1 prevents the dedifferentiation of lymphatic endothelial cells

被引：12

作者：

Bixel, M. Gabriele

Adams, Ralf H. ^{[1
]}

机构：

[1] Max Planck Inst Mol Biomed, Dept Tissue Morphogenesis, D-48149 Munster, Germany

来源：

GENES & DEVELOPMENT | 2008年 / 22卷 / 23期

关键词：

Lymphatic endothelial cells; blood endothelial cells; lymphangiogenesis; reprogramming; Prox1; siRNA;

D O I：

10.1101/gad.1751908

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cell differentiation occurs mostly during a specific developmental time window and is irreversible. The homeobox-containing transcription factor Prox1 is a master regulator of lymphatic endothelial cell differentiation in the embryo. A study by Johnson et al. (pp 3282-3291) published in this issue of Genes & Development now shows that continued expression of Prox1 is required to maintain lymphatic endothelial cell identity even in adult mice. These findings indicate that Prox1 is essential for the differentiation and function of the lymphatic vasculature throughout life.

引用

收藏

页码：3232 / 3235

页数：4

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