Simulation of primary cervical cancer screening by the PAPNET system in an unscreened, high-risk community

被引:14
作者
Michelow, PM
Hlongwane, NF
Leiman, G
机构
[1] S AFRICAN INST MED RES,CYTOPATHOL UNIT,DEPT ANAT PATHOL,SCH PATHOL,ZA-2000 JOHANNESBURG,SOUTH AFRICA
[2] UNIV WITWATERSRAND,JOHANNESBURG,SOUTH AFRICA
关键词
cervix neoplasms; cervical smears; mass screening; PAPNET;
D O I
10.1159/000332311
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
OBJECTIVE: To evaluate the performance of the PAPNET system as a primary cervical cancer screening modality in an unscreened population with a high prevalence of cervical cancer and its precursor lesions. STUDY DESIGN: Consecutive cervical smears from 3,106 women, screened and reported in the usual manner, were submitted for analysis by the PAPNET system. The original manual screening diagnoses were compared with those obtained by PAPNET analysis. By inclusion of normal and abnormal smears, this evaluation not only provided quality assurance for the laboratory but also simulated primary screening by automation. RESULTS: Comparison of the two methods of screening showed statistically significant superiority of the PAPNET over conventional screening (89.6% vs. 63.8%, respectively) in low grade lesions, including atypical squamous and atypical glandular cells of uncertain significance (ASCUS and AGUS, respectively) and low grade squamous intraepithelial lesion. Conversely, there plas no significant difference between PAPNET and manual detection (87.5%, vs. 94.6%) for more significant abnormalities, including high grade squamous intraepithelial lesions and invasive carcinoma. CONCLUSION: The PAPNET system, which would probably not be affordable as a quality assurance modality only in the public health sector of this country, was shown to be more than sufficiently effective as a primary screening method for the large numbers of women likely to undergo cervical cancer screening in anticipated mass population programs.
引用
收藏
页码:88 / 92
页数:5
相关论文
共 24 条
[1]   EVALUATION OF PAPNET(TM) SYSTEM FOR RESCREENING OF NEGATIVE CERVICAL SMEARS [J].
ASHFAQ, R ;
LIANG, Y ;
SABOORIAN, MH .
DIAGNOSTIC CYTOPATHOLOGY, 1995, 13 (01) :31-36
[2]  
BLOCH B, 1994, S AFR MED J, V84, P318
[3]   NEURAL-NETWORK PROCESSING CAN PROVIDE MEANS TO CATCH ERRORS THAT SLIP THROUGH HUMAN SCREENING OF PAP SMEARS [J].
BOON, ME ;
KOK, LP .
DIAGNOSTIC CYTOPATHOLOGY, 1993, 9 (04) :411-416
[4]  
BOON ME, 1995, CELL VISION, V9, P411
[5]   Medical progress - Cancer of the uterine cervix [J].
Cannistra, SA ;
Niloff, JM .
NEW ENGLAND JOURNAL OF MEDICINE, 1996, 334 (16) :1030-1038
[6]  
FONN S, 1993, NATL SCREENING POLIC
[7]  
GRANT MC, 1982, S AFR MED J, V61, P918
[8]  
KeyhaniRofagha S, 1996, DIAGN CYTOPATHOL, V14, P316, DOI 10.1002/(SICI)1097-0339(199605)14:4<316::AID-DC7>3.0.CO
[9]  
2-D
[10]   THE PAPANICOLAOU TEST FOR CERVICAL-CANCER DETECTION - A TRIUMPH AND A TRAGEDY [J].
KOSS, LG .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1989, 261 (05) :737-743