Stress by heat shock induces massive down regulation of genes and allows differential allelic expression of the Gal/GaINAc lectin in Entamoeba histolytica

被引：67

作者：

Weber, Christian

Guigon, Ghislaine

Bouchier, Christiane

Frangeul, Lionel

Moreira, Sandrine

Sismeiro, Odile

Gouyette, Catherine

Mirelman, David

Coppee, Jean Yves

Guillen, Nancy

机构：

[1] Inst Pasteur, INSERM, Unite Biol Cellulaire Parasitisme, F-75724 Paris 15, France

[2] Inst Pasteur, Pasteur Genopole Ile De France, F-75724 Paris 15, France

[3] Weizmann Inst Sci, Dept Biol Chem, IL-76100 Rehovot, Israel

来源：

EUKARYOTIC CELL | 2006年 / 5卷 / 05期

关键词：

D O I：

10.1128/EC.5.5.871-875.2006

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Gene expression analysis by microarray assay revealed that when exposed to stress, Entamoeba histolytica exhibits a specific heat shock response, together with a dramatic overall reduction in gene transcription as well as differential allelic expression of key genes participating in virulence, such as the galactose/N-acetylgalactosamine (Gal/GalNAC) lectin.

引用

页码：871 / 875

页数：5

共 22 条

[1] A mitochondrial-type hsp70 gene of Entamoeba histolytica [J].

Bakatselou, C ;

Clark, CG .

ARCHIVES OF MEDICAL RESEARCH, 2000, 31 (04) :S176-S177

[2] The LINES and SINES of Entamoeba histolytica:: Comparative analysis and genomic distribution [J].

Bakre, AA ;

Rawal, K ;

Ramaswamy, R ;

Bhattacharya, A ;

Bhattacharya, S .

EXPERIMENTAL PARASITOLOGY, 2005, 110 (03) :207-213

[3]

Ballinger CA, 1999, MOL CELL BIOL, V19, P4535

[4] The intestinal protozoan parasite Entamoeba histolytica contains 20 cysteine protease genes, of which only a small subset is expressed during in vitro cultivation [J].

Bruchhaus, I ;

Loftus, BJ ;

Hall, N ;

Tannich, E .

EUKARYOTIC CELL, 2003, 2 (03) :501-509

[5] An unusual surface peroxiredoxin protects invasive Entamoeba histolytica from oxidant attack [J].

Choi, MH ;

Sajed, D ;

Poole, L ;

Hirata, K ;

Herdman, S ;

Torian, BE ;

Reed, SL .

MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 2005, 143 (01) :80-89

[6]

Elsas LJ, 1998, GENET MED, V1, P40

[7] Chaperones get in touch: The hip-hop connection [J].

Frydman, J ;

Hohfeld, J .

TRENDS IN BIOCHEMICAL SCIENCES, 1997, 22 (03) :87-92

[8] Identification of Entamoeba histolytica thiol-specific antioxidant as a GalNAc lectin-associated protein [J].

Hughes, MA ;

Lee, CW ;

Holm, CF ;

Ghosh, S ;

Mills, A ;

Lockhart, LA ;

Reed, SL ;

Mann, BJ .

MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 2003, 127 (02) :113-120

[9] The FK506-binding protein of the malaria parasite, Plasmodium falciparum, is a FK506-sensitive chaperone with FK506-independent calcineurin-inhibitory activity [J].

Kumar, R ;

Adams, B ;

Musiyenko, A ;

Shulyayeva, O ;

Barik, S .

MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 2005, 141 (02) :163-173

[10] The genome of the protist parasite Entamoeba histolytica [J].

Loftus, B ;

Anderson, I ;

Davies, R ;

Alsmark, UCM ;

Samuelson, J ;

Amedeo, P ;

Roncaglia, P ;

Berriman, M ;

Hirt, RP ;

Mann, BJ ;

Nozaki, T ;

Suh, B ;

Pop, M ;

Duchene, M ;

Ackers, J ;

Tannich, E ;

Leippe, M ;

Hofer, M ;

Bruchhaus, I ;

Willhoeft, U ;

Bhattacharya, A ;

Chillingworth, T ;

Churcher, C ;

Hance, Z ;

Harris, B ;

Harris, D ;

Jagels, K ;

Moule, S ;

Mungall, K ;

Ormond, D ;

Squares, R ;

Whitehead, S ;

Quail, MA ;

Rabbinowitsch, E ;

Norbertczak, H ;

Price, C ;

Wang, Z ;

Guillén, N ;

Gilchrist, C ;

Stroup, SE ;

Bhattacharya, S ;

Lohia, A ;

Foster, PG ;

Sicheritz-Ponten, T ;

Weber, C ;

Singh, U ;

Mukherjee, C ;

El-Sayed, NM ;

Petri, WA ;

Clark, CG .

NATURE, 2005, 433 (7028) :865-868

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