Changes of mRNA expression of enkephalin and prodynorphin in hippocampus of rats with chronic immobilization stress

被引：21

作者：

Chen, Jia-Xu ^{[1
]}

Li, Wei ^{[1
]}

Zhao, Xin ^{[1
]}

Yang, Jian-Xin ^{[1
]}

Xu, Hong-Yan ^{[1
]}

Wang, Zhu-Feng ^{[1
]}

Yue, Guang-Xin ^{[1
]}

机构：

[1] Beijing Univ Tradit Chinese Med, TCM Diag Dept, Sch Basic Med Sci, Beijing 100029, Peoples R China

来源：

WORLD JOURNAL OF GASTROENTEROLOGY | 2004年 / 10卷 / 17期

基金：

中国国家自然科学基金;

关键词：

D O I：

10.3748/wjg.v10.i17.2547

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

AIM: To observe the changes of enkephalin mRNA and prodynorphin mRNA in hippocampus of rats induced by chronic immobilization stress. METHODS: Thirty rats were randomly divided into three groups of 10 each: the normal control group (group A), the group induced by chronic immobilization stress for 7 d (group B) and the group induced by chronic immobilization stress for 21 d (group C). The changes of the enkephalin mRNA and prodynorphin mRNA in the rat hippocampus were detected by reverse transcription-polymerase chain reaction (RT-PCR). RESULTS: Expression levels of enkephalin mRNA and prodynorphin mRNA in rat hippocampus were significantly increased under chronic immobilization stress, and the expression of prodynorphin mRNA in the rat hippocampus in group C was remarkably higher than that in group B (0.624 +/- 0.026; n = 5; P<0.01). CONCLUSION: The increased enkephalin mRNA and prodynorphin mRNA gene expressions in rat hippocampus were involved in chronic stress.

引用

页码：2547 / 2549

页数：3

共 16 条

[1] GLUCOCORTICOID REGULATION OF PREPROENKEPHALIN GENE-EXPRESSION IN THE RAT FOREBRAIN [J].