A clonogenic bone marrow progenitor specific for macrophages and dendritic cells

被引：796

作者：

Fogg, DK

Sibon, C

Miled, C

Jung, S

Aucouturier, P

Littman, DR

Cumano, A

Geissmann, F ^{[1
]}

机构：

[1] Necker Enfants Malad Inst, Avenir Team, Lab Mononucl Phagocyte Biol, INSERM, F-75015 Paris, France

[2] INSERM, U712, F-75012 Paris, France

[3] Weizmann Inst Sci, Dept Immunol, IL-76100 Rehovot, Israel

[4] NYU, Sch Med, Skirball Inst Biomol Med, Howard Hughes Med Inst, New York, NY 10016 USA

[5] INSERM, U668, F-75015 Paris, France

[6] Inst Pasteur, Lymphocyte Dev Unit, F-75015 Paris, France

[7] Univ Paris, Descartes Fac Med, Hop Necker Enfants Malad, Dept Pathol, F-75015 Paris, France

[8] Assistance Publ Hop Paris, F-75015 Paris, France

来源：

SCIENCE | 2006年 / 311卷 / 5757期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1126/science.1117729

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 [理学]; 0710 [生物学]; 09 [农学];

摘要：

Macrophages and dendritic cells (DCs) are crucial for immune and inflammatory responses and belong to a network of cells that has been termed the mononuclear phagocyte system (MPS). However, the origin and lineage of these cells remain poorly understood. Here, we describe the isolation and clonal analysis of a mouse bone marrow progenitor that is specific for monocytes, several macrophage subsets, and resident spleen DCs in vivo. It was also possible to recapitulate this differentiation in vitro by using treatment with the cytokines macrophage colony-stimulating factor and granulocyte-macrophage colony-stimulating factor. Thus, macrophages and DCs appear to renew from a common progenitor, providing a cellular and molecular basis for the concept of the MPS.

引用

页码：83 / 87

页数：5

共 30 条

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