Eicosapentaenoic-acid-derived isoprostanes: Synthesis and discovery of two major isoprostanes

被引：11

作者：

Chang, Chih-Tsung ^{[1
,2
]}

Patel, Pranav ^{[1
,2
]}

Kang, Namin ^{[1
,2
]}

Lawson, John A. ^{[3
,4
]}

Song, Wen-Liang ^{[3
,4
]}

Powell, William S. ^{[5
]}

FitzGerald, Garret A. ^{[3
,4
]}

Rokach, Joshua ^{[1
,2
]}

机构：

[1] Florida Inst Technol, Claude Pepper Inst, Melbourne, FL 32901 USA

[2] Florida Inst Technol, Dept Chem, Melbourne, FL 32901 USA

[3] Univ Penn, Dept Pharmacol, Philadelphia, PA 19104 USA

[4] Univ Penn, Inst Translat Med & Therapeut, Philadelphia, PA 19104 USA

[5] McGill Univ, Meakins Christie Labs, Dept Med, Montreal, PQ H2X 2P2, Canada

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2008年 / 18卷 / 20期

基金：

美国国家卫生研究院; 美国国家科学基金会; 加拿大健康研究院;

关键词：

eicosapentaenoic acid; EPA; docosahexaenoic acid; DHA; arachidonic acid; AA; isoprostane; iP;

D O I：

10.1016/j.bmcl.2008.09.008

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The stereospecific synthesis of two all-syn-EPA-derived isoprostanes (iPs), 5-epi-8,12-iso-iPF(3 alpha)-VI 17 and 8,12-iso-iPF(3 alpha)-VI 18, has been accomplished. These two synthetic probes have been used to discover and identify their presence in human urine. The eventual quantitative measurement of these two iPs may be a valuable index of oxidative stress in people with eicosapentaenoic acid-(EPA) and docosahexaenoic acid-(DHA) enriched phospholipids. (c) 2008 Elsevier Ltd. All rights reserved.

引用

页码：5523 / 5527

页数：5

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