Reactivity of thionitrate esters: Putative intermediates in nitrovasodilator activity

被引:18
作者
Artz, JD
Yang, KX
Lock, J
Sanchez, C
Bennett, BM
Thatcher, GRJ
机构
[1] QUEENS UNIV, DEPT CHEM, KINGSTON, ON K7L 3N6, CANADA
[2] QUEENS UNIV, DEPT PHARMACOL & TOXICOL, KINGSTON, ON K7L 3N6, CANADA
关键词
D O I
10.1039/cc9960000927
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
tert-Butyl thionitrate decomposes rapidly in neutral aqueous solution to yield nitric oxide, sulfonyl and sulfinyl species, but does not activate soluble guanylyl cyclase.
引用
收藏
页码:927 / 928
页数:2
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