A Mouse Speciation Gene Encodes a Meiotic Histone H3 Methyltransferase

被引：332

作者：

Mihola, Ondrej ^{[1
]}

Trachtulec, Zdenek ^{[1
]}

Vlcek, Cestmir ^{[1
]}

Schimenti, John C. ^{[2
]}

Forejt, Jiri ^{[1
]}

机构：

[1] Acad Sci Czech Republic, Inst Mol Genet, CR-14220 Prague, Czech Republic

[2] Cornell Univ, Coll Vet Med, Dept Biomed Sci, Ctr Vertebrate Genom, Ithaca, NY 14853 USA

来源：

SCIENCE | 2009年 / 323卷 / 5912期

关键词：

HYBRID STERILITY; CHROMOSOME; 17; WILD MOUSE; DROSOPHILA; MUSCULUS; STRAINS; REGION; MICE;

D O I：

10.1126/science.1163601

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Speciation genes restrict gene flow between the incipient species and related taxa. Three decades ago, we mapped a mammalian speciation gene, hybrid sterility 1 (Hst1), in the intersubspecific hybrids of house mouse. Here, we identify this gene as Prdm9, encoding a histone H3 lysine 4 trimethyltransferase. We rescued infertility in male hybrids with bacterial artificial chromosomes carrying Prdm9 from a strain with the "fertility" Hst1(f) allele. Sterile hybrids display down-regulated microrchidia 2B (Morc2b) and fail to compartmentalize gamma H2AX into the pachynema sex (XY) body. These defects, seen also in Prdm9-null mutants, are rescued by the Prdm9 transgene. Identification of a vertebrate hybrid sterility gene reveals a role for epigenetics in speciation and opens a window to a hybrid sterility gene network.

引用

页码：373 / 375

页数：3

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