Polymer-supported O-methylisourea:: A new reagent for the O-methylation of carboxylic acids

被引：32

作者：

Crosignani, S

White, PD

Linclau, B ^{[1
]}

机构：

[1] Univ Southampton, Dept Chem, Combinatorial Ctr Excellence, Southampton SO17 1BJ, Hants, England

[2] Novabiochem CN Biosci UK Ltd, Beeston NG9 2JR, England

来源：

ORGANIC LETTERS | 2002年 / 4卷 / 06期

关键词：

D O I：

10.1021/ol025633s

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] A solid-supported O-methylisourea reagent has been prepared in one step starting from commercially available solid-supported carbodiimide. The isourea reagent has been successfully used for the preparation of methyl esters from the corresponding carboxylic acids. The crude products obtained after resin filtration and solvent evaporation are generally obtained in >98% purity.

引用

页码：1035 / 1037

页数：3

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