Association of tapasin and COPI provides a mechanism for the retrograde transport of major histocompatibility complex (MHC) class I molecules from the Golgi complex to the endoplasmic reticulum
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Paulsson, KM
Kleijmeer, MJ
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机构:Lund Univ, Inst Tumor Immunol, S-22362 Lund, Sweden
Kleijmeer, MJ
Griffith, J
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机构:Lund Univ, Inst Tumor Immunol, S-22362 Lund, Sweden
Griffith, J
Jevon, M
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机构:Lund Univ, Inst Tumor Immunol, S-22362 Lund, Sweden
Jevon, M
Chen, SW
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机构:Lund Univ, Inst Tumor Immunol, S-22362 Lund, Sweden
Chen, SW
Anderson, PO
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机构:Lund Univ, Inst Tumor Immunol, S-22362 Lund, Sweden
Anderson, PO
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Sjögren, HO
Li, SL
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机构:Lund Univ, Inst Tumor Immunol, S-22362 Lund, Sweden
Li, SL
Wang, P
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机构:Lund Univ, Inst Tumor Immunol, S-22362 Lund, Sweden
Wang, P
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[1] Lund Univ, Inst Tumor Immunol, S-22362 Lund, Sweden
Tapasin is a subunit of the transporter associated with antigen processing (TAP). It associates with the major histocompatibility complex (MHC) class I. We show that tapasin interacts with beta- and gamma-subunits of COPI coatomer. COPI retrieves membrane proteins from the Golgi network back to the endoplasmic reticulum (ER). The COPI subunit-associated tapasin also interacts with MHC class I molecules suggesting that tapasin acts as the cargo receptor for packing MHC class I molecules as cargo proteins into COPI-coated vesicles. In tapasin mutant cells, neither TAP nor MHC class I are detected in association with the COPI coatomer. Interestingly, tapasin-associated MHC class I molecules are antigenic peptide-receptive and detected in both the ER and the Golgi. Our data suggest that tapasin is required for the COPI vesicle-mediated retrograde transport of immature MHC class I molecules from the Golgi network to the ER.
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Yale Univ, Sch Med, Howard Hughes Med Inst, Immunobiol Sect, New Haven, CT 06520 USAYale Univ, Sch Med, Howard Hughes Med Inst, Immunobiol Sect, New Haven, CT 06520 USA
Cresswell, P
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Bangia, N
Dick, T
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Yale Univ, Sch Med, Howard Hughes Med Inst, Immunobiol Sect, New Haven, CT 06520 USAYale Univ, Sch Med, Howard Hughes Med Inst, Immunobiol Sect, New Haven, CT 06520 USA
Dick, T
Diedrich, G
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Yale Univ, Sch Med, Howard Hughes Med Inst, Immunobiol Sect, New Haven, CT 06520 USAYale Univ, Sch Med, Howard Hughes Med Inst, Immunobiol Sect, New Haven, CT 06520 USA
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Yale Univ, Sch Med, Howard Hughes Med Inst, Immunobiol Sect, New Haven, CT 06520 USAYale Univ, Sch Med, Howard Hughes Med Inst, Immunobiol Sect, New Haven, CT 06520 USA
Cresswell, P
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Bangia, N
Dick, T
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Yale Univ, Sch Med, Howard Hughes Med Inst, Immunobiol Sect, New Haven, CT 06520 USAYale Univ, Sch Med, Howard Hughes Med Inst, Immunobiol Sect, New Haven, CT 06520 USA
Dick, T
Diedrich, G
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Yale Univ, Sch Med, Howard Hughes Med Inst, Immunobiol Sect, New Haven, CT 06520 USAYale Univ, Sch Med, Howard Hughes Med Inst, Immunobiol Sect, New Haven, CT 06520 USA