Chemokine Receptor Antagonists

被引：72

作者：

Pease, James ^{[2
,3
]}

Horuk, Richard ^{[1
]}

机构：

[1] Univ Calif Davis, Dept Pharmacol, Davis, CA 95616 USA

[2] Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, Leukocyte Biol Sect, Fac Med,MRC, London SW7 2AZ, England

[3] Univ London Imperial Coll Sci Technol & Med, Asthma UK Ctr Allerg Mech Asthma, London SW7 2AZ, England

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2012年 / 55卷 / 22期

关键词：

COLLAGEN-INDUCED ARTHRITIS; MACROPHAGE INFLAMMATORY PROTEIN-1-ALPHA; ACTIVE CCR5 ANTAGONISTS; MONOCYTE CHEMOATTRACTANT PROTEIN-1; INDUCED AIRWAY INFLAMMATION; SMALL-MOLECULE ANTAGONISTS; CELL LEUKEMIA-LYMPHOMA; CENTRAL-NERVOUS-SYSTEM; RHEUMATOID-ARTHRITIS; ANTI-HIV-1; AGENTS;

D O I：

10.1021/jm300682j

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

[No abstract available]

引用

页码：9363 / 9392

页数：30

共 253 条

[1]

Impaired neuropathic pain responses in mice lacking the chemokine receptor CCR2 [J].

Abbadie, C ;

Lindia, JA ;

Cumiskey, AM ;

Peterson, LB ;

Mudgett, JS ;

Bayne, EK ;

DeMartino, JA ;

MacIntyre, DE ;

Forrest, MJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (13) :7947-7952

[2]

Abbadie C., 2006, Patent No. [US 20060205761, 20060205761]

[3]

Constitutive homing of mast cell progenitors to the intestine depends on autologous expression of the chemokine receptor CXCR2 [J].

Abonia, JP ;

Austen, KF ;

Rollins, BJ ;

Joshi, SK ;

Flavell, RA ;

Kuziel, WA ;

Koni, PA ;

Gurish, MF .

BLOOD, 2005, 105 (11) :4308-4313

[4]

Pharmacokinetics and short-term safety of 873140, a novel CCR5 antagonist, in healthy adult subjects [J].

Adkison, KK ;

Shachoy-Clark, A ;

Fang, L ;

Lou, Y ;

O'Mara, K ;

Berrey, MM ;

Piscitelli, SC .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2005, 49 (07) :2802-2806

[5]

Aidsmap, 2 CO HALTS CCR5 INH

[6]

AIDSMEDS, MERCK TERM DEV ITS H

[7]

Fingolimod is a potential novel therapy for multiple sclerosis [J].

Aktas, Orhan ;

Kuery, Patrick ;

Kieseier, Bernd ;

Hartung, Hans-Peter .

NATURE REVIEWS NEUROLOGY, 2010, 6 (07) :373-382

[8]

2-Arylpropionic CXC chemokine receptor 1 (CXCR1) ligands as novel noncompetitive CXCL8 inhibitors [J].

Allegretti, M ;

Bertini, R ;

Cesta, MC ;

Bizzarri, C ;

Di Bitondo, R ;

Di Cioccio, V ;

Galliera, E ;

Berdini, V ;

Topai, A ;

Zampella, G ;

Russo, V ;

Di Bello, N ;

Nano, G ;

Nicolini, L ;

Locati, M ;

Fantucci, P ;

Florio, S ;

Colotta, F .

JOURNAL OF MEDICINAL CHEMISTRY, 2005, 48 (13) :4312-4331

[9]

Pharmacological blockade of CCR1 ameliorates murine arthritis and alters cytokine networks in vivo [J].

Amat, M. ;

Benjamim, C. F. ;

Williams, L. M. ;

Prats, N. ;

Terricabras, E. ;

Beleta, J. ;

Kunkel, S. L. ;

Godessart, N. .

BRITISH JOURNAL OF PHARMACOLOGY, 2006, 149 (06) :666-675

[10]

An intracellular allosteric site for a specific class of antagonists of the CC chemokine G protein-coupled receptors CCR4 and CCR5 [J].

Andrews, Glen ;

Jones, Carolyn ;

Wreggett, Keith A. .

MOLECULAR PHARMACOLOGY, 2008, 73 (03) :855-867

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