Interferon-γ-inducing factor (IL-18) and interferon-γ in inflammatory CNS diseases

被引：65

作者：

Fassbender, K

Mielke, O

Bertsch, T

Muehlhauser, F

Hennerici, M

Kurimoto, M

Rossol, S

机构：

[1] Univ Heidelberg, Klinikum Mannheim, Dept Neurol, D-68135 Mannheim, Germany

[2] Univ Heidelberg, Klinikum Mannheim, Dept Internal Med, D-68135 Mannheim, Germany

[3] Univ Heidelberg, Klinikum Mannheim, Inst Clin Chem, D-68135 Mannheim, Germany

[4] Hayashibara Labs Inc, Fujisaki Inst, Okayama, Japan

来源：

NEUROLOGY | 1999年 / 53卷 / 05期

关键词：

interleukin-18; bacterial meningitis; MS;

D O I：

10.1212/WNL.53.5.1104

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Objective: To examine the intrathecal production of a newly identified cytokine, interferon-gamma-inducing factor (IL-18), together with interferon-gamma itself, in inflammatory diseases of the CNS (i.e., bacterial meningitis, viral meningoencephalitis, and MS). Results: IL-18 concentrations in CSF were significantly increased in bacterial meningitis and tended toward increased levels in viral meningoencephalitis. In contrast, IL-18 was detectable only in a few patients with MS and healthy controls. Interestingly, interferon-gamma was significantly increased selectively in CSF of patients with viral meningoencephalitis. Conclusion: The observation of an intrathecal release of IL-18 in patients with meningitis argues for a pathophysiologic role of this novel cytokine in immunity against invading microorganisms the CNS.

引用

页码：1104 / 1106

页数：3

共 16 条

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