Involvement of the mt1 melatonin receptor in human breast cancer

被引：130

作者：

Ram, PT

Dai, J

Yuan, L

Dong, C

Kiefer, TL

Lai, L

Hill, SM ^{[1
]}

机构：

[1] Tulane Univ, Ctr Hlth Sci, Dept Struct & Cellular Biol, New Orleans, LA 70112 USA

[2] Tulane Univ, Ctr Hlth Sci, Tulane Canc Ctr, New Orleans, LA 70112 USA

[3] Tulane Univ, Ctr Hlth Sci, Grad Program Mol & Cellular Biol, New Orleans, LA 70112 USA

来源：

CANCER LETTERS | 2002年 / 179卷 / 02期

关键词：

melatonin; breast cancers; mt1; receptors; retinoic orphan receptor alpha;

D O I：

10.1016/S0304-3835(01)00873-4

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Two putative melatonin receptors have been described including the cell surface G-protein-linked receptors, mt1 and MT2, and the nuclear retinoic orphan receptor alpha (RORalpha). The mL1 receptor, but not the MT2 receptor, is expressed in human breast tumor cell lines, and melatonin-induced growth suppression can be mimicked by the mt1 and MT2 agonist, AMMTC, and blocked by the antagonist, CBPT. RORalpha receptors are also expressed in MCF-7 breast cancer cells and the putative RORalpha agonist CPG-52608 inhibits MCF-7 cell growth but with a very different dose-response than melatonin. Finally, melatonin and AMMTC, but not CPG-52608, can repress RORalpha transcriptional activity in MCF-7 cells. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：141 / 150

页数：10

共 18 条

[1] Pineal gland hormone melatonin binds and activates an orphan of the nuclear receptor superfamily (vol 269, pg 28531, 1994) [J].