Endometrial Abnormality in Women With Polycystic Ovary Syndrome

被引：103

作者：

Shang, Kewei ^{[1
]}

Jia, Xiao ^{[1
]}

Qiao, Jie ^{[2
]}

Kang, Jihong ^{[1
]}

Guan, Youfei ^{[1
]}

机构：

[1] Peking Univ, Hlth Sci Ctr, Dept Physiol & Pathophysiol, Beijing 100191, Peoples R China

[2] Peking Univ, Hosp 3, Dept Obstet & Gynecol, Beijing 100191, Peoples R China

来源：

REPRODUCTIVE SCIENCES | 2012年 / 19卷 / 07期

基金：

中国国家自然科学基金;

关键词：

polycystic ovary syndrome; infertility; endometrial abnormality; PROGESTERONE RECEPTOR-A; INSULIN-RESISTANCE; ESTROGEN-RECEPTOR; GENE-EXPRESSION; UNTREATED WOMEN; GROWTH-FACTOR; SECRETORY ENDOMETRIA; AROMATASE INHIBITORS; OVULATION INDUCTION; CLOMIPHENE CITRATE;

D O I：

10.1177/1933719111430993

中图分类号：

R71 [妇产科学];

学科分类号：

100211 [妇产科学];

摘要：

Polycystic ovary syndrome (PCOS) is the most common endocrinopathy associated with infertility and metabolic disorder in women of reproductive age. Although the clinical and biochemical features are heterogeneous with individuals, the most widely accepted clinical characteristics of PCOS are oligo- or anovulation combined with hyperandrogenism. With the higher rate of implantation failure after induction of ovulation or higher risk of spontaneous miscarriage after pregnancy, the reduced fertility is apparently attributed not only to anovulation but also to endometrial dysfunction in patients with PCOS. Here we review the features of the endometrial abnormalities in women with PCOS. The ability to improve the endometrial functions is of potential therapeutic targets to increase reproductive outcome of women with PCOS.

引用

页码：674 / 683

页数：10

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